Are the severe injuries of cutaneous leishmaniasis caused by an exacerbated Th1 response?

Summary American tegumentary leishmaniasis (ATL) is a disease whose clinical features are strongly related to the type of immune response it induces. Herein we report an atypical presentation of cutaneous leishmaniasis in a woman with a severe and extensive sore located in her leg, and we describe t...

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Bibliographic Details
Published in:Parasite immunology 2012-08, Vol.34 (8-9), p.440-443
Main Authors: NICODEMO, A. C., AMATO, V. S., MIRANDA, A. M., FLOETER-WINTER, L. M. F., ZAMPIERI, R. A., FERNADES, E. R., DUARTE, M. I. S.
Format: Article
Language:English
Subjects:
Adult
cutaneous leishmaniasis
Cytokines - immunology
Female
Humans
immune response
Leg - pathology
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - pathology
Skin - immunology
Skin - pathology
Th1 Cells - immunology
Toll-Like Receptor 3 - biosynthesis
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Summary:Summary American tegumentary leishmaniasis (ATL) is a disease whose clinical features are strongly related to the type of immune response it induces. Herein we report an atypical presentation of cutaneous leishmaniasis in a woman with a severe and extensive sore located in her leg, and we describe the differences between the usual local immune response in ATL and the local immune response in this patient. We observed an intense inflammatory response characterized by Th1 cells and cytokines with conspicuous expression of Toll‐like receptor 3 (TLR‐3). Few parasites were present, but there was an extensive tissue damage. We also discuss the immunological factors that could be related to the atypical presentation.
ISSN:0141-9838
1365-3024
DOI:10.1111/j.1365-3024.2012.01372.x