Association of chromosome 8q24 variants with prostate cancer risk in the Siberian region of Russia and meta-analysis

Compelling evidence demonstrates the importance of chromosome 8q24 as a locus of susceptibility to prostate cancer. In this work, the association of common 8q24 variants, rs6983267 and rs1447295, with a sporadic risk of prostate cancer was analyzed in the Russian population of Siberia. For this purp...

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Bibliographic Details
Published in:Molecular biology (New York) 2012-04, Vol.46 (2), p.210-217
Main Authors: Os’kina, N. A., Boyarskikh, U. A., Lazarev, A. F., Petrova, V. D., Ganov, D. I., Tonacheva, O. G., Lifshits, G. I., Filipenko, M. L.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
chromosome 8
Chromosomes
Data processing
Genomics. Transcriptomics
Haplotypes
Human Genetics
Life Sciences
Meta-analysis
Molecular biology
Polymorphism
Population genetics
Prostate cancer
Reviews
Risk factors
Single-nucleotide polymorphism
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Summary:Compelling evidence demonstrates the importance of chromosome 8q24 as a locus of susceptibility to prostate cancer. In this work, the association of common 8q24 variants, rs6983267 and rs1447295, with a sporadic risk of prostate cancer was analyzed in the Russian population of Siberia. For this purpose, the above polymorphisms were genotyped in 393 cases and 384 control individuals. The A allele of rs1447295 was significantly associated with prostate cancer risk ( OR [CI 95%] = 1.74 [1.26–2.4], p = 7.8 × 10 −4 ). The common G-A haplotype of rs6983267-rs1447295 also showed association with prostate cancer risk in Russians ( OR [CI 95%] = 2.03 [1.1–3.75], p = 0.02). A meta-analysis combining our data with previously published results was performed to better evaluate the association between the SNPs studied and prostate cancer risk; its results strongly supported the association for both loci ( p < 10 −6 ). Thus, our study has confirmed the association of chromosome 8q24 with a risk of prostate cancer.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893312020124