Prognostic Significance of Telomerase Activity and Human Telomerase Reverse Transcriptase Expression in Ampullary Carcinoma

Background Telomerase activity and human telomerase reverse transcriptase (TERT) have been reported as markers of tumor aggressiveness and poor prognosis in several digestive cancers. In the present study, we examined telomerase activity and TERT expression in ampullary carcinoma to determine whethe...

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Bibliographic Details
Published in:Annals of surgical oncology 2012-09, Vol.19 (9), p.3072-3080
Main Authors: Sakabe, Ryutaro, Murakami, Yoshiaki, Uemura, Kenichiro, Sudo, Takeshi, Hashimoto, Yasushi, Kondo, Naru, Nakashima, Akira, Ohge, Hiroki, Sueda, Taijiro, Hiyama, Eiso
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Ampulla of Vater - metabolism
Ampulla of Vater - pathology
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - metabolism
Carcinoma - enzymology
Carcinoma - pathology
Carcinoma - therapy
Chemotherapy, Adjuvant
Common Bile Duct Neoplasms - enzymology
Common Bile Duct Neoplasms - pathology
Common Bile Duct Neoplasms - therapy
Deoxycytidine - administration & dosage
Deoxycytidine - analogs & derivatives
Drug Combinations
Female
Humans
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Oncology
Oxonic Acid - administration & dosage
Pancreaticoduodenectomy
Prognosis
Proportional Hazards Models
Retrospective Studies
Surgery
Surgical Oncology
Tegafur - administration & dosage
Telomerase - metabolism
Translational Research and Biomarkers
Young Adult
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Summary:Background Telomerase activity and human telomerase reverse transcriptase (TERT) have been reported as markers of tumor aggressiveness and poor prognosis in several digestive cancers. In the present study, we examined telomerase activity and TERT expression in ampullary carcinoma to determine whether these parameters could be used as indicators of aggressiveness and prognosis. Methods Telomerase activity was analyzed by using the telomeric repeat amplification protocol assay, and TERT was examined by immunohistochemistry in ampullary carcinoma tissue samples resected from 46 patients. Results Telomerase activity was detected in 42 (91.3%) ampullary carcinomas and 27 (58.7%) showed high activity, whereas TERT expression was detected in 35 (76.1%), including 21 with weak expression and 14 with strong expression. Univariate analysis revealed that histological grade ( P  = 0.029), tumor depth ( P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-012-2245-2