Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity stu...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (77), p.9649-9651
Main Authors: Wachter, Erin, Heidary, David K, Howerton, Brock S, Parkin, Sean, Glazer, Edith C
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Proliferation - drug effects
Chemical communication
DNA - chemistry
DNA Damage
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Light
Models, Molecular
Molecular Structure
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Photochemical Processes
Photochemotherapy
Pyridines - chemistry
Quinolines - chemistry
Ruthenium - chemistry
Structure-Activity Relationship
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Summary:Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc33359g