Immunoregulatory Properties of Human Stem Cells of Mesenchymal and Ectodermal Origin after Their Transplantation to BALB/c Mice

We studied immunoregulatory properties of cultured human stem cells of mesenchymal and ectodermal origins after their administration to mice. Xenotransplantation of mesenchymal stem cells from human placenta reduced the number of CD11c + dendritic cells in mouse spleens, but did not affect activatio...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-05, Vol.153 (1), p.118-123
Main Authors: Karalkin, P. A., Lupatov, A. Yu, Burunova, V. V., Holodenko, I. V., Yarygin, K. N., Moldaver, M. V., Poltavtseva, R. A., Pavlovich, S. V., Sukhikh, G. T.
Format: Article
Language:English
Subjects:
Animals
B cells
Biomedical and Life Sciences
Biomedicine
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cell Biology
Dendritic cells
Ectoderm - cytology
Humans
Immunity, Cellular - immunology
Immunohistochemistry
Internal Medicine
Laboratory Medicine
Male
Mesoderm - cytology
Mice
Mice, Inbred BALB C
Pathology
Stem Cell Transplantation
Stem cells
Stem Cells - cytology
Stem Cells - immunology
T cells
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
Transplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied immunoregulatory properties of cultured human stem cells of mesenchymal and ectodermal origins after their administration to mice. Xenotransplantation of mesenchymal stem cells from human placenta reduced the number of CD11c + dendritic cells in mouse spleens, but did not affect activation of dendritic cells from mouse spleen in culture. It was also shown that splenocytes isolated from animals 10 days after transplantation of mesenchymal stem cells more actively proliferated in response to the polyclonal stimulation. At the same time, transplantation of neither mesenchymal nor neural stem cells affected the ratio of CD4 + /CD8 + T cells and their total content in the peripheral blood in comparison with the corresponding parameters in the control groups.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1658-z