Three-Dimensional Electrospun Poly(Lactide-Co-ɛ-Caprolactone) for Small-Diameter Vascular Grafts

Nanofibers have been applied to tissue engineering scaffolds because fiber diameters are of the same scale as the physical structure of protein fibrils in the native extracellular matrix. In this study, we utilized cell matrix engineering combined with cell sheet matrix and electrospinning technolog...

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Bibliographic Details
Published in:Tissue engineering. Part A 2012-08, Vol.18 (15-16), p.168-1616
Main Authors: Mun, Cho Hay, Jung, Youngmee, Kim, Sang-Heon, Lee, Sun-Hee, Kim, Hee Chan, Kwon, Il Keun, Kim, Soo Hyun
Format: Article
Language:English
Subjects:
Animals
Blood Vessel Prosthesis
Blood Vessels - anatomy & histology
Blood Vessels - ultrastructure
Cardiovascular disease
Cell Proliferation - drug effects
Cell Survival - drug effects
Cells, Cultured
DNA - metabolism
Extracellular matrix
Fibrils
Male
Materials Testing
Mechanical properties
Myocytes, Smooth Muscle - cytology
Myocytes, Smooth Muscle - drug effects
Myocytes, Smooth Muscle - metabolism
Nanomaterials
Original Articles
Phospholipase C
Polyesters - pharmacology
Protein structure
Rabbits
scaffolds
Smooth muscle
Tensile strength
Tensile Strength - drug effects
Tissue engineering
Tissue Engineering - methods
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Summary:Nanofibers have been applied to tissue engineering scaffolds because fiber diameters are of the same scale as the physical structure of protein fibrils in the native extracellular matrix. In this study, we utilized cell matrix engineering combined with cell sheet matrix and electrospinning technologies. We studied small-diameter vascular grafts in vitro by seeding smooth muscle cells onto electrospun poly(lactide-co-ɛ-caprolactone) (PLCL) scaffolds, culturing and constructing a three-dimensional network. The vascular grafts constructed using cell matrix engineering were similar to the native vessels in their mechanical properties, such as tensile strength, tensile strain, and e-modulus. Also, they had a self-sealing property more improved than GORE-TEX because PLCL has compatible elasticity. Small-diameter vascular grafts constructed using matrix engineering have the potential to be suitable for vascular grafts.
ISSN:1937-3341
1937-335X
DOI:10.1089/ten.tea.2011.0695