Fatal flecainide intoxication

Two fatalities resulting from suicidal ingestion of flecainide are described. The decedents, ages 33 and 15, were otherwise healthy; both took their mothers' medications. In one case, from electrocardiographic data, there was found a high-grade conduction block with idioventricular rhythm. Bloo...

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Bibliographic Details
Published in:Journal of analytical toxicology 1993-11, Vol.17 (7), p.434-435
Main Authors: ROGERS, C, ANDERSON, D. T, RIBE, J. K, LAKSHMANAN SATHYAVAGISWARAN
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Autopsy
Biological and medical sciences
Blood
Chromatography, Gas
Data processing
Drug intoxications. Doping
Female
Flecainide - analysis
Flecainide - poisoning
Gas chromatography
Humans
Intoxication
Male
Mass spectroscopy
Medical sciences
Nerve conduction
Pharmacology. Drug treatments
Rhythms
Suicide
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Description
Summary:Two fatalities resulting from suicidal ingestion of flecainide are described. The decedents, ages 33 and 15, were otherwise healthy; both took their mothers' medications. In one case, from electrocardiographic data, there was found a high-grade conduction block with idioventricular rhythm. Blood and tissue samples from autopsy were analyzed for flecainide by gas chromatography/nitrogen-phosphorous detection and gas chromatography/mass spectrometry. Blood concentrations of 93.7 and 100 mg/L flecainide were found.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/17.7.434