Interpenetrating polymer network microspheres of hydroxy propyl methyl cellulose/poly (vinyl alcohol) for control release of ciprofloxacin hydrochloride

Hydroxypropylmethylcellulose and Poly (vinyl alcohol) blend microspheres were prepared by water in oil emulsion method and Ciprofloxacin Hydrochloride (CFHcl) was loaded into the interpenetrating polymer network (IPN) microspheres that are crosslinked with glutaraldehyde (GA). Blend microspheres wer...

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Bibliographic Details
Published in:Cellulose (London) 2011-04, Vol.18 (2), p.349-357
Main Authors: YerriSwamy, B, Venkata Prasad, C, Reedy, C. L. N, Mallikarjuna, B, Rao, K. Chowdoji, Subha, M. C. S
Format: Article
Language:English
Subjects:
Alcohol
Bioorganic Chemistry
Blend
Cellulose
Ceramics
Chemistry
Chemistry and Materials Science
Ciproflaxin hydrochloride
Composites
Controlled release
Crosslinking
Drug delivery
Electron micrographs
Fourier transforms
Glass
Glutaraldehyde
Infrared spectroscopy
Interpenetrating networks
Microspheres
Natural Materials
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
Polymers
Scanning electron microscopy
Spectrum analysis
Sustainable Development
X-ray diffraction
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Summary:Hydroxypropylmethylcellulose and Poly (vinyl alcohol) blend microspheres were prepared by water in oil emulsion method and Ciprofloxacin Hydrochloride (CFHcl) was loaded into the interpenetrating polymer network (IPN) microspheres that are crosslinked with glutaraldehyde (GA). Blend microspheres were characterized using Fourier transform infrared Spectroscopy (FT-IR), Scanning electron microscopy, X-ray diffraction and Differential scanning Calorimetry. FTIR spectra results confirmed crosslinking reaction between -OH groups of Poly (vinyl alcohol) and -CHO groups of glutaraldehyde. Scanning electron micrograph showed the formation of plain, uniform and smooth microspheres. X-ray diffraction and thermal studies of plain and drug loaded microspheres indicates that the drug is dispersed at the molecular level in the IPN matrix. In vitro dissolution experiments were performed in pH 7.4 buffer medium at 35 °C which indicates a sustained and controlled release of ciprofloxacin hydrochloride (CFHcl) from the IPN microspheres up to 10 h.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-010-9475-x