In situnanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

We report here for the first time the in vitrolocalization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-12, Vol.48 (6), p.910-912
Main Authors: Dubar, Faustine, Bohic, Sylvain, Slomianny, Christian, Morin, Jean-Charles, Thomas, Patrick, Kalamou, Hadidjatou, Guerardel, Yann, Cloetens, Peter, Khalife, Jamal, Biot, Christophe
Format: Article
Language:English
Subjects:
Plasmodium
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Summary:We report here for the first time the in vitrolocalization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16211j