Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival

Summary Although TNFRSF17 (also designated as B‐cell maturation antigen (BCMA)) is expressed on tumour cells in B‐cell malignancies, it has not been found in serum. The present study found that BCMA concentrations were higher in the supernatants of cultured bone marrow mononuclear cells from multipl...

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Bibliographic Details
Published in:British journal of haematology 2012-09, Vol.158 (6), p.727-738
Main Authors: Sanchez, Eric, Li, Mingjie, Kitto, Alex, Li, Jennifer, Wang, Cathy S., Kirk, Dylan T., Yellin, Ori, Nichols, Cydney M., Dreyer, Marissa P., Ahles, Cameryn P., Robinson, Austin, Madden, Erik, Waterman, Gabriel N., Swift, Regina A., Bonavida, Benjamin, Boccia, Ralph, Vescio, Robert A., Crowley, John, Chen, Haiming, Berenson, James R.
Format: Article
Language:English
Subjects:
Animals
B-cell maturation antigen
B-Cell Maturation Antigen - analysis
Biological and medical sciences
biomarkers
Bone marrow
Bone Marrow - chemistry
Boronic Acids - therapeutic use
Bortezomib
Cell Membrane - chemistry
Cell survival
Culture Media, Conditioned - chemistry
Cyclophosphamide
Cyclophosphamide - therapeutic use
Enzyme-Linked Immunosorbent Assay - methods
Flow Cytometry
Hematologic and hematopoietic diseases
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin G - blood
Immunoglobulinopathies
Immunopathology
in vivo
Kaplan-Meier Estimate
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocytes (mononuclear)
Lymphocytes B
Malignancy
Medical sciences
Melphalan
Mice
Mice, SCID
Monoclonal gammopathy
Monoclonal Gammopathy of Undetermined Significance - blood
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - metabolism
Multiple Myeloma - mortality
Multiple Myeloma - pathology
Neoplasm Proteins - analysis
Neoplasm Transplantation
Plasma Cells - chemistry
Pyrazines - therapeutic use
serum
Survival
Tumor Burden
Tumor Cells, Cultured - metabolism
Xenografts
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Summary:Summary Although TNFRSF17 (also designated as B‐cell maturation antigen (BCMA)) is expressed on tumour cells in B‐cell malignancies, it has not been found in serum. The present study found that BCMA concentrations were higher in the supernatants of cultured bone marrow mononuclear cells from multiple myeloma (MM) patients than in healthy subjects. Serum BCMA levels were measured in samples from MM patients (n = 209), monoclonal gammopathy of undetermined significance (MGUS) individuals (n = 23) and age‐matched controls (n = 40). BCMA was detected in the serum of untreated MM patients (n = 50) and levels were higher than in MGUS patients (P = 0·0157) and healthy subjects (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2012.09241.x