Epigenetic changes associated with oocyte aging

It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age.Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process.Here,we review the epigenetic alt...

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Bibliographic Details
Published in:Science China. Life sciences 2012-08, Vol.55 (8), p.670-676
Main Authors: Liang, XingWei, Ma, JunYu, Schatten, Heide, Sun, QingYuan
Format: Article
Language:English
Subjects:
Acetylation
Aging
Aging - genetics
Aging - metabolism
Aging - pathology
Animals
Biomedical and Life Sciences
DNA Methylation
DNA甲基化
Epigenesis, Genetic
epigenetics
Female
Histones
Histones - metabolism
Humans
Life Sciences
Maternal Age
Methylation
Oocytes
Oocytes - metabolism
Oocytes - pathology
Review
Reviews
卵母细胞质量
组蛋白乙酰化
细胞老化
老化过程
表观遗传学
遗传变化
遗传完整性
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Summary:It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age.Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process.Here,we review the epigenetic alterations,mainly focused on DNA methylation,histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age.Furthermore,we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-012-4354-3