Loading…
Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats
Dietary polyphenols present in Punica granatum (pomegranate), such as ellagitannins and ellagic acid (EA) have shown to exert anti-inflammatory and antioxidant properties. This study was designed to evaluate the effects of a dietary EA-enriched pomegranate extract (PE) in a murine chronic model of C...
Saved in:
Published in: | Pharmacological research 2012-09, Vol.66 (3), p.235-242 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c389t-9fff9f40b014f62bd699860582e608374c096d7e0ad68c20c440a399baaaeeb3 |
---|---|
cites | cdi_FETCH-LOGICAL-c389t-9fff9f40b014f62bd699860582e608374c096d7e0ad68c20c440a399baaaeeb3 |
container_end_page | 242 |
container_issue | 3 |
container_start_page | 235 |
container_title | Pharmacological research |
container_volume | 66 |
creator | Rosillo, Maria Angeles Sánchez-Hidalgo, Marina Cárdeno, Ana Aparicio-Soto, Marina Sánchez-Fidalgo, Susana Villegas, Isabel de la Lastra, Catalina Alarcón |
description | Dietary polyphenols present in Punica granatum (pomegranate), such as ellagitannins and ellagic acid (EA) have shown to exert anti-inflammatory and antioxidant properties. This study was designed to evaluate the effects of a dietary EA-enriched pomegranate extract (PE) in a murine chronic model of Cronh's disease (CD). Colonic injury was induced by intracolonic instillation of trinitrobenzensulfonic acid (TNBS). Rats were fed with different diets during 30 days before TNBS instillation and 2 weeks before killing: (i) standard, (ii) PE 250mg/kg/day, (iii) PE 500mg/kg/day, (iv) EA 10mg/kg/day and (v) EA 10mg/kg/day enriched-PE 250mg/kg/day. Inflammation response was assessed by histology and MPO activity and TNF-α production. Besides, colonic expressions of iNOS, COX-2, p38, JNK, pERK1/2 MAPKs, IKBα and nuclear p65 NF-κB were studied by western blotting. MPO activity and the TNF-α levels were significantly reduced in dietary fed rats when compared with TNBS group. Similarly, PE and an EA-enriched PE diets drastically decreased COX-2 and iNOS overexpression, reduced MAPKs phosporylation and prevented the nuclear NF-κB translocation. Dietary supplementation of EA contributes in the beneficial effect of PE in this experimental colitis model and may be a novel therapeutic strategy to manage inflammatory bowel disease (IBD). |
doi_str_mv | 10.1016/j.phrs.2012.05.006 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1093467339</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1043661812001144</els_id><sourcerecordid>1093467339</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-9fff9f40b014f62bd699860582e608374c096d7e0ad68c20c440a399baaaeeb3</originalsourceid><addsrcrecordid>eNqNkUtv1TAQhS0EoqXwB1ggL9kkjJ1cx5bYoJaXVIlN95bjjHt9ldjBdnj8exxuYYlYzWj0nSPNOYS8ZNAyYOLNqV2PKbccGG_h0AKIR-SSgRINY1I83ve-a4Rg8oI8y_kEAKpn8JRccC6GAaS8JN9vPBaTftK8reuMC4Ziio-BRkdNoDjP5t5baqyfGgzJ2yNOdI0L3icTTEGKP0oytlBTCoatXjK1xxRDFdk4_54-uNksy9nXB5pMyc_JE2fmjC8e5hW5-_D-7vpTc_vl4-frd7eN7aQqjXLOKdfDCKx3go-TUEoKOEiOAmQ39La-Ow0IZhLScrB9D6ZTajTGII7dFXl9tl1T_LphLnrx2e5fBYxb1jWtrhdD16n_QLkENgwHVlF-Rm2KOSd0ek1-qSlWSO_V6JPeq9F7NRoOulZTRa8e_Ldxwemv5E8XFXh7BrDm8c1j0tl6DBYnn9AWPUX_L_9fwBmiGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1028017751</pqid></control><display><type>article</type><title>Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats</title><source>ScienceDirect Journals</source><creator>Rosillo, Maria Angeles ; Sánchez-Hidalgo, Marina ; Cárdeno, Ana ; Aparicio-Soto, Marina ; Sánchez-Fidalgo, Susana ; Villegas, Isabel ; de la Lastra, Catalina Alarcón</creator><creatorcontrib>Rosillo, Maria Angeles ; Sánchez-Hidalgo, Marina ; Cárdeno, Ana ; Aparicio-Soto, Marina ; Sánchez-Fidalgo, Susana ; Villegas, Isabel ; de la Lastra, Catalina Alarcón</creatorcontrib><description>Dietary polyphenols present in Punica granatum (pomegranate), such as ellagitannins and ellagic acid (EA) have shown to exert anti-inflammatory and antioxidant properties. This study was designed to evaluate the effects of a dietary EA-enriched pomegranate extract (PE) in a murine chronic model of Cronh's disease (CD). Colonic injury was induced by intracolonic instillation of trinitrobenzensulfonic acid (TNBS). Rats were fed with different diets during 30 days before TNBS instillation and 2 weeks before killing: (i) standard, (ii) PE 250mg/kg/day, (iii) PE 500mg/kg/day, (iv) EA 10mg/kg/day and (v) EA 10mg/kg/day enriched-PE 250mg/kg/day. Inflammation response was assessed by histology and MPO activity and TNF-α production. Besides, colonic expressions of iNOS, COX-2, p38, JNK, pERK1/2 MAPKs, IKBα and nuclear p65 NF-κB were studied by western blotting. MPO activity and the TNF-α levels were significantly reduced in dietary fed rats when compared with TNBS group. Similarly, PE and an EA-enriched PE diets drastically decreased COX-2 and iNOS overexpression, reduced MAPKs phosporylation and prevented the nuclear NF-κB translocation. Dietary supplementation of EA contributes in the beneficial effect of PE in this experimental colitis model and may be a novel therapeutic strategy to manage inflammatory bowel disease (IBD).</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2012.05.006</identifier><identifier>PMID: 22677088</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animal models ; Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Antioxidants ; c-Jun amino-terminal kinase ; Colitis ; Colitis - chemically induced ; Colitis - drug therapy ; Colitis - metabolism ; Colitis - pathology ; Colon - drug effects ; Colon - metabolism ; Colon - pathology ; COX-2 ; Crohn Disease - drug therapy ; Crohn Disease - metabolism ; Crohn Disease - pathology ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-2 ; Dietary Supplements ; Disease Models, Animal ; Ellagic acid ; Ellagic Acid - pharmacology ; I-kappa B Proteins - metabolism ; Inflammatory bowel diseases ; Injuries ; Interferon-alpha - metabolism ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Male ; MAP kinase ; MAP Kinase Kinase 4 - metabolism ; MAP Kinase Signaling System - drug effects ; NF- Kappa B protein ; NF-kappa B - metabolism ; NF-KappaB Inhibitor alpha ; Nitric Oxide Synthase Type II - metabolism ; Nitric-oxide synthase ; Nuclear transport ; p38 Mitogen-Activated Protein Kinases - metabolism ; Peroxidase - metabolism ; Phosphorylation - drug effects ; Plant Extracts - pharmacokinetics ; Polyphenols ; Polyphenols - pharmacology ; Pomegranate ; Punica granatum ; Punicaceae - chemistry ; Rats ; Rats, Wistar ; Signal Transduction - drug effects ; TNBS-induced colitis ; TNF-α ; Trinitrobenzenesulfonic Acid - adverse effects ; Western blotting</subject><ispartof>Pharmacological research, 2012-09, Vol.66 (3), p.235-242</ispartof><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-9fff9f40b014f62bd699860582e608374c096d7e0ad68c20c440a399baaaeeb3</citedby><cites>FETCH-LOGICAL-c389t-9fff9f40b014f62bd699860582e608374c096d7e0ad68c20c440a399baaaeeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043661812001144$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22677088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosillo, Maria Angeles</creatorcontrib><creatorcontrib>Sánchez-Hidalgo, Marina</creatorcontrib><creatorcontrib>Cárdeno, Ana</creatorcontrib><creatorcontrib>Aparicio-Soto, Marina</creatorcontrib><creatorcontrib>Sánchez-Fidalgo, Susana</creatorcontrib><creatorcontrib>Villegas, Isabel</creatorcontrib><creatorcontrib>de la Lastra, Catalina Alarcón</creatorcontrib><title>Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>Dietary polyphenols present in Punica granatum (pomegranate), such as ellagitannins and ellagic acid (EA) have shown to exert anti-inflammatory and antioxidant properties. This study was designed to evaluate the effects of a dietary EA-enriched pomegranate extract (PE) in a murine chronic model of Cronh's disease (CD). Colonic injury was induced by intracolonic instillation of trinitrobenzensulfonic acid (TNBS). Rats were fed with different diets during 30 days before TNBS instillation and 2 weeks before killing: (i) standard, (ii) PE 250mg/kg/day, (iii) PE 500mg/kg/day, (iv) EA 10mg/kg/day and (v) EA 10mg/kg/day enriched-PE 250mg/kg/day. Inflammation response was assessed by histology and MPO activity and TNF-α production. Besides, colonic expressions of iNOS, COX-2, p38, JNK, pERK1/2 MAPKs, IKBα and nuclear p65 NF-κB were studied by western blotting. MPO activity and the TNF-α levels were significantly reduced in dietary fed rats when compared with TNBS group. Similarly, PE and an EA-enriched PE diets drastically decreased COX-2 and iNOS overexpression, reduced MAPKs phosporylation and prevented the nuclear NF-κB translocation. Dietary supplementation of EA contributes in the beneficial effect of PE in this experimental colitis model and may be a novel therapeutic strategy to manage inflammatory bowel disease (IBD).</description><subject>Animal models</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants</subject><subject>c-Jun amino-terminal kinase</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Colitis - metabolism</subject><subject>Colitis - pathology</subject><subject>Colon - drug effects</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>COX-2</subject><subject>Crohn Disease - drug therapy</subject><subject>Crohn Disease - metabolism</subject><subject>Crohn Disease - pathology</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase-2</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Ellagic acid</subject><subject>Ellagic Acid - pharmacology</subject><subject>I-kappa B Proteins - metabolism</subject><subject>Inflammatory bowel diseases</subject><subject>Injuries</subject><subject>Interferon-alpha - metabolism</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>MAP kinase</subject><subject>MAP Kinase Kinase 4 - metabolism</subject><subject>MAP Kinase Signaling System - drug effects</subject><subject>NF- Kappa B protein</subject><subject>NF-kappa B - metabolism</subject><subject>NF-KappaB Inhibitor alpha</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Nitric-oxide synthase</subject><subject>Nuclear transport</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Peroxidase - metabolism</subject><subject>Phosphorylation - drug effects</subject><subject>Plant Extracts - pharmacokinetics</subject><subject>Polyphenols</subject><subject>Polyphenols - pharmacology</subject><subject>Pomegranate</subject><subject>Punica granatum</subject><subject>Punicaceae - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Signal Transduction - drug effects</subject><subject>TNBS-induced colitis</subject><subject>TNF-α</subject><subject>Trinitrobenzenesulfonic Acid - adverse effects</subject><subject>Western blotting</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1TAQhS0EoqXwB1ggL9kkjJ1cx5bYoJaXVIlN95bjjHt9ldjBdnj8exxuYYlYzWj0nSPNOYS8ZNAyYOLNqV2PKbccGG_h0AKIR-SSgRINY1I83ve-a4Rg8oI8y_kEAKpn8JRccC6GAaS8JN9vPBaTftK8reuMC4Ziio-BRkdNoDjP5t5baqyfGgzJ2yNOdI0L3icTTEGKP0oytlBTCoatXjK1xxRDFdk4_54-uNksy9nXB5pMyc_JE2fmjC8e5hW5-_D-7vpTc_vl4-frd7eN7aQqjXLOKdfDCKx3go-TUEoKOEiOAmQ39La-Ow0IZhLScrB9D6ZTajTGII7dFXl9tl1T_LphLnrx2e5fBYxb1jWtrhdD16n_QLkENgwHVlF-Rm2KOSd0ek1-qSlWSO_V6JPeq9F7NRoOulZTRa8e_Ldxwemv5E8XFXh7BrDm8c1j0tl6DBYnn9AWPUX_L_9fwBmiGA</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Rosillo, Maria Angeles</creator><creator>Sánchez-Hidalgo, Marina</creator><creator>Cárdeno, Ana</creator><creator>Aparicio-Soto, Marina</creator><creator>Sánchez-Fidalgo, Susana</creator><creator>Villegas, Isabel</creator><creator>de la Lastra, Catalina Alarcón</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201209</creationdate><title>Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats</title><author>Rosillo, Maria Angeles ; Sánchez-Hidalgo, Marina ; Cárdeno, Ana ; Aparicio-Soto, Marina ; Sánchez-Fidalgo, Susana ; Villegas, Isabel ; de la Lastra, Catalina Alarcón</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-9fff9f40b014f62bd699860582e608374c096d7e0ad68c20c440a399baaaeeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants</topic><topic>c-Jun amino-terminal kinase</topic><topic>Colitis</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Colitis - metabolism</topic><topic>Colitis - pathology</topic><topic>Colon - drug effects</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>COX-2</topic><topic>Crohn Disease - drug therapy</topic><topic>Crohn Disease - metabolism</topic><topic>Crohn Disease - pathology</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-2</topic><topic>Dietary Supplements</topic><topic>Disease Models, Animal</topic><topic>Ellagic acid</topic><topic>Ellagic Acid - pharmacology</topic><topic>I-kappa B Proteins - metabolism</topic><topic>Inflammatory bowel diseases</topic><topic>Injuries</topic><topic>Interferon-alpha - metabolism</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>MAP kinase</topic><topic>MAP Kinase Kinase 4 - metabolism</topic><topic>MAP Kinase Signaling System - drug effects</topic><topic>NF- Kappa B protein</topic><topic>NF-kappa B - metabolism</topic><topic>NF-KappaB Inhibitor alpha</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Nitric-oxide synthase</topic><topic>Nuclear transport</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Peroxidase - metabolism</topic><topic>Phosphorylation - drug effects</topic><topic>Plant Extracts - pharmacokinetics</topic><topic>Polyphenols</topic><topic>Polyphenols - pharmacology</topic><topic>Pomegranate</topic><topic>Punica granatum</topic><topic>Punicaceae - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Signal Transduction - drug effects</topic><topic>TNBS-induced colitis</topic><topic>TNF-α</topic><topic>Trinitrobenzenesulfonic Acid - adverse effects</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosillo, Maria Angeles</creatorcontrib><creatorcontrib>Sánchez-Hidalgo, Marina</creatorcontrib><creatorcontrib>Cárdeno, Ana</creatorcontrib><creatorcontrib>Aparicio-Soto, Marina</creatorcontrib><creatorcontrib>Sánchez-Fidalgo, Susana</creatorcontrib><creatorcontrib>Villegas, Isabel</creatorcontrib><creatorcontrib>de la Lastra, Catalina Alarcón</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosillo, Maria Angeles</au><au>Sánchez-Hidalgo, Marina</au><au>Cárdeno, Ana</au><au>Aparicio-Soto, Marina</au><au>Sánchez-Fidalgo, Susana</au><au>Villegas, Isabel</au><au>de la Lastra, Catalina Alarcón</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2012-09</date><risdate>2012</risdate><volume>66</volume><issue>3</issue><spage>235</spage><epage>242</epage><pages>235-242</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>Dietary polyphenols present in Punica granatum (pomegranate), such as ellagitannins and ellagic acid (EA) have shown to exert anti-inflammatory and antioxidant properties. This study was designed to evaluate the effects of a dietary EA-enriched pomegranate extract (PE) in a murine chronic model of Cronh's disease (CD). Colonic injury was induced by intracolonic instillation of trinitrobenzensulfonic acid (TNBS). Rats were fed with different diets during 30 days before TNBS instillation and 2 weeks before killing: (i) standard, (ii) PE 250mg/kg/day, (iii) PE 500mg/kg/day, (iv) EA 10mg/kg/day and (v) EA 10mg/kg/day enriched-PE 250mg/kg/day. Inflammation response was assessed by histology and MPO activity and TNF-α production. Besides, colonic expressions of iNOS, COX-2, p38, JNK, pERK1/2 MAPKs, IKBα and nuclear p65 NF-κB were studied by western blotting. MPO activity and the TNF-α levels were significantly reduced in dietary fed rats when compared with TNBS group. Similarly, PE and an EA-enriched PE diets drastically decreased COX-2 and iNOS overexpression, reduced MAPKs phosporylation and prevented the nuclear NF-κB translocation. Dietary supplementation of EA contributes in the beneficial effect of PE in this experimental colitis model and may be a novel therapeutic strategy to manage inflammatory bowel disease (IBD).</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>22677088</pmid><doi>10.1016/j.phrs.2012.05.006</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1043-6618 |
ispartof | Pharmacological research, 2012-09, Vol.66 (3), p.235-242 |
issn | 1043-6618 1096-1186 |
language | eng |
recordid | cdi_proquest_miscellaneous_1093467339 |
source | ScienceDirect Journals |
subjects | Animal models Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antioxidants c-Jun amino-terminal kinase Colitis Colitis - chemically induced Colitis - drug therapy Colitis - metabolism Colitis - pathology Colon - drug effects Colon - metabolism Colon - pathology COX-2 Crohn Disease - drug therapy Crohn Disease - metabolism Crohn Disease - pathology Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Dietary Supplements Disease Models, Animal Ellagic acid Ellagic Acid - pharmacology I-kappa B Proteins - metabolism Inflammatory bowel diseases Injuries Interferon-alpha - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male MAP kinase MAP Kinase Kinase 4 - metabolism MAP Kinase Signaling System - drug effects NF- Kappa B protein NF-kappa B - metabolism NF-KappaB Inhibitor alpha Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Nuclear transport p38 Mitogen-Activated Protein Kinases - metabolism Peroxidase - metabolism Phosphorylation - drug effects Plant Extracts - pharmacokinetics Polyphenols Polyphenols - pharmacology Pomegranate Punica granatum Punicaceae - chemistry Rats Rats, Wistar Signal Transduction - drug effects TNBS-induced colitis TNF-α Trinitrobenzenesulfonic Acid - adverse effects Western blotting |
title | Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A54%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20supplementation%20of%20an%20ellagic%20acid-enriched%20pomegranate%20extract%20attenuates%20chronic%20colonic%20inflammation%20in%20rats&rft.jtitle=Pharmacological%20research&rft.au=Rosillo,%20Maria%20Angeles&rft.date=2012-09&rft.volume=66&rft.issue=3&rft.spage=235&rft.epage=242&rft.pages=235-242&rft.issn=1043-6618&rft.eissn=1096-1186&rft_id=info:doi/10.1016/j.phrs.2012.05.006&rft_dat=%3Cproquest_cross%3E1093467339%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c389t-9fff9f40b014f62bd699860582e608374c096d7e0ad68c20c440a399baaaeeb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1028017751&rft_id=info:pmid/22677088&rfr_iscdi=true |