Docetaxel-loaded composite nanoparticles formed by a temperature-induced phase transition for cancer therapy

Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid so...

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Bibliographic Details
Published in:Journal of bioactive and compatible polymers 2012-09, Vol.27 (5), p.441-452
Main Authors: Yuk, Soon H, Oh, Keun S, Park, Jinah, Lee, Eun H, Kim, Kwangmeyung, Kwon, Ick C
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Exact sciences and technology
Forms of application and semi-finished materials
General pharmacology
Medical sciences
Miscellaneous
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymer industry, paints, wood
Technology of polymers
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Summary:Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid soybean oil/Tween 80 containing docetaxel. The phase transition was performed at low temperature to avoid degradation. The docetaxel composite nanoparticles were injected into the tail veins of tumor-bearing mice to evaluate the composite delivery system for the release pattern and the tumor growth. The tumor-targeting capability of composite nanoparticles was verified by noninvasive live animal imaging for the time-dependent excretion profile, the in vivo biodistribution, and the circulation time.
ISSN:0883-9115
1530-8030
DOI:10.1177/0883911512448752