Lighting up Skeletal Biology by Fluorescent Imaging

Skeletal development and bone homeostasis are dynamic but coordinated cellular process that involves proliferation, migration and differentiation. Molecular biology and genome science promoted this realm of biomedical science by elucidating cell lineages and essential molecules and their interaction...

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Bibliographic Details
Published in:Journal of oral biosciences 2011-01, Vol.53 (2), p.97-108
Main Authors: Iimura, Tadahiro, Sugiyama, Mayu, Watanabe, Takashi, Nakane, Ayako, Makino, Yuji, Yamaguchi, Akira
Format: Article
Language:English
Subjects:
Bone imaging
Bone marrow
bone metabolism
Bone turnover
Cell lineage
Cell migration
Differentiation
Fluorescence
fluorescent protein
Genomes
imaging
microscopy
Morphometry
Reviews
skeletal development
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Summary:Skeletal development and bone homeostasis are dynamic but coordinated cellular process that involves proliferation, migration and differentiation. Molecular biology and genome science promoted this realm of biomedical science by elucidating cell lineages and essential molecules and their interactions. Fluorescence live imaging has made it possible to quantitatively analyze multi-cellular processes in 4 dimensions, thus providing coherent understanding of distinct levels of description from molecular levels to the tissue, organ and organism. Application of this approach has given further insight into and comprehension of the dynamic process of, not a mere description of the molecular hierarchy, skeletal biology. In this review paper, how fluorescent imaging has shed new light on the skeletal biology will be discussed. We introduce several current topics in the application of fluorescent imaging on skeletal patterning, morphometry of bone cells and cellular behavior in bone marrow.
ISSN:1349-0079
1880-3865
DOI:10.1016/S1349-0079(11)80012-5