Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference

Double agents: Dual‐action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding as...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-10, Vol.50 (42), p.9852-9856
Main Authors: Xue, Xuan, Pasparakis, George, Halliday, Nigel, Winzer, Klaus, Howdle, Steven M., Cramphorn, Christopher J., Cameron, Neil R., Gardner, Paul M., Davis, Benjamin G., Fernández-Trillo, Francisco, Alexander, Cameron
Format: Article
Language:English
Subjects:
cell adhesion
Cell Adhesion - drug effects
luminescence
Molecular Structure
polymers
Polymers - chemical synthesis
Polymers - chemistry
Polymers - pharmacology
quorum sensing
Quorum Sensing - drug effects
Species Specificity
Structure-Activity Relationship
Surface Properties
therapeutics
Vibrio - cytology
Vibrio - drug effects
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Summary:Double agents: Dual‐action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201103130