The value of apolipoprotein B/A1 ratio in the diagnosis of metabolic syndrome in a Korean population

Summary Objective  The ratio of apolipoprotein B (apoB) to apolipoprotein A1 (apoA1) has been reported to be associated with the metabolic syndrome (MetS). However, the optimal cut‐off value of apoB/A1 ratio for detecting subjects with MetS has remained undetermined. In the present study, we aimed t...

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Published in:Clinical endocrinology (Oxford) 2012-11, Vol.77 (5), p.699-706
Main Authors: Jung, Chang Hee, Hwang, Jenie Yoonoo, Yu, Ji Hee, Shin, Mi Seon, Bae, Sung Jin, Park, Joong-Yeol, Kim, Hong-Kyu, Lee, Woo Je
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Biological and medical sciences
Cross-Sectional Studies
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Korea
Male
Medical sciences
Metabolic diseases
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Middle Aged
Miscellaneous
Other metabolic disorders
Vertebrates: endocrinology
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Summary:Summary Objective  The ratio of apolipoprotein B (apoB) to apolipoprotein A1 (apoA1) has been reported to be associated with the metabolic syndrome (MetS). However, the optimal cut‐off value of apoB/A1 ratio for detecting subjects with MetS has remained undetermined. In the present study, we aimed to investigate whether apoB/A1 ratio can be an indicator of MetS and to determine the optimal cut‐off value of apoB/A1 ratio in detecting subjects with MetS in a Korean population. Design  This cross‐sectional study was conducted at the Asan Medical Center, Seoul, Republic of Korea. Subjects and measurements  We collected the data of 10 940 subjects who participated in a routine health screening examination regarding conventional risk factors and serum levels of apoB and apoA1. Results  The odds for MetS were significantly higher in the highest compared with the lowest apoB/A1 ratio quartiles, after adjustment for confounding variables, in both men [odds ratio (OR) = 4·07, 95% CI = 3·42–4·84] and women (OR = 8·41, 95% CI = 5·85–12·08). The optimal apoB/A1 ratio cut‐off value for the detection of MetS was 0·65, which had a sensitivity of 63·5% and a specificity of 61·3% (area under the curve = 0·67, 95% CI = 0·66–0·68, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2012.04329.x