Reproductive Performance and Early Postnatal Development in Interleukin (IL)-13-Deficient Mice

OBJECTIVE The purpose of this study was to assess the effect of interleukin (IL)‐13 deficiency on fertility and reproductive performance of adult mice and on morphological and behavioral development of the offspring. METHODS Wild‐type and homozygous IL‐13‐deficient (KO) mice were grouped by genotype...

Full description

Saved in:
Bibliographic Details
Published in:Birth defects research. Part B. Developmental and reproductive toxicology 2012-10, Vol.95 (5), p.346-353
Main Authors: Wright, David J., Adkins, Karissa K., Minck, Daniel R., Bailey, Steven, Warner, Garvin, Leach, Michael W.
Format: Article
Language:English
Subjects:
Acoustics
Animal reproduction
Animals
Animals, Newborn
Avoidance Learning
Bone and Bones - pathology
Crosses, Genetic
Cytokines
development
Estrous Cycle
Female
Fertility
Fetuses
genotype
Growth and Development
IL-13
Interleukin-13 - deficiency
Interleukin-13 - metabolism
Male
Mice
Mice, Inbred C57BL
Organ Size
Reflex, Startle
Reproduction
Rodents
Sexual Maturation
Sperm
Uterus - pathology
Viscera - pathology
Weight Gain
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVE The purpose of this study was to assess the effect of interleukin (IL)‐13 deficiency on fertility and reproductive performance of adult mice and on morphological and behavioral development of the offspring. METHODS Wild‐type and homozygous IL‐13‐deficient (KO) mice were grouped by genotype, and male and female mice were mated within each group. Adult (F0) mice were evaluated for reproductive performance, and development was assessed in F1 fetuses on gestation day 18, and in F1 pups to postnatal day 35. RESULTS In F0 males, there were no differences in the number of males that mated or impregnated females, or in total sperm count or sperm motility, between the wild‐type and KO groups. In F0 females, there were no observed genotype‐related differences in fertility, length of gestation, number of viable fetuses per litter, or viability of offspring. There were no differences in embryo‐fetal development (external/palate, skeletal, visceral) of the F1 fetuses between genotypes. Similarly, IL‐13 deficiency had no impact on any postnatal parameters assessed including reflex, sexual maturation, learning, and memory. CONCLUSIONS IL‐13 deficiency had no observed effect on reproductive performance or morphological and behavioral development in mice.
ISSN:1542-9733
1542-9741
DOI:10.1002/bdrb.21023