The Impact of Age on Outcome of Embryonal and Alveolar Rhabdomyosarcoma Patients. A Multicenter Study

The prognosis of rhabdomyosarcoma (RMS) in children and adolescents has improved since the introduction of multi-agent chemotherapy. However, outcome data of adults with RMS are scarce. This multicenter retrospective study investigated the effect of age on outcome of RMS. Data were collected from th...

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Bibliographic Details
Published in:Anticancer research 2012-10, Vol.32 (10), p.4485-4497
Main Authors: VAN GAAL, Jorieke C, VAN DER GRAAF, Winette T. A, RIKHOF, Bart, VAN HOESEL, Quirinis G. C. M, TEERENSTRA, Steven, SUURMEIJER, Albert J. H, FLUCKE, Uta E, LOEFFEN, Jan L. C. M, SLEIJFER, Stefan, DE BONT, Eveline S. J. M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Child
Child, Preschool
Disease-Free Survival
Diseases of the osteoarticular system
Female
Humans
Infant
Male
Medical sciences
Middle Aged
Prognosis
Retrospective Studies
Rhabdomyosarcoma, Alveolar - mortality
Rhabdomyosarcoma, Alveolar - secondary
Rhabdomyosarcoma, Embryonal - mortality
Rhabdomyosarcoma, Embryonal - secondary
Treatment Outcome
Tumors
Tumors of striated muscle and skeleton
Young Adult
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Summary:The prognosis of rhabdomyosarcoma (RMS) in children and adolescents has improved since the introduction of multi-agent chemotherapy. However, outcome data of adults with RMS are scarce. This multicenter retrospective study investigated the effect of age on outcome of RMS. Data were collected from three Dutch University Medical Centers between 1977-2009. The effect of age and clinical prognostic factors on relapse-free and disease-specific survival (DSS) were analyzed. Age as a continuous variable predicted poor survival in multivariate analysis. Five-year DSS was highest for non-metastatic embryonal RMS, followed by non-metastatic alveolar RMS and was poor in metastatic disease. Higher age correlated with unfavorable histological subtype (alveolar RMS) and with metastatic disease at presentation in embryonal RMS. In non-metastatic embryonal RMS and in all alveolar RMS, higher age was an adverse prognostic factor of outcome. This study indicates that age is a negative predictor of survival in patients with embryonal and alveolar RMS.
ISSN:0250-7005
1791-7530