Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients

Purpose To describe anticipated health-related quality of life (HRQL) for different hypothetical strategies of febrile neutropenia (FN) management in adult cancer patients. Methods Seventy-eight adult cancer patients were enrolled. Our study considered four different hypothetical treatment strategie...

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Bibliographic Details
Published in:Supportive care in cancer 2012-11, Vol.20 (11), p.2755-2764
Main Authors: Teuffel, O., Cheng, S., Ethier, M. C., Diorio, C., Martino, J., Mayo, C., Wing, R., Sung, L., Alibhai, S. M. H.
Format: Article
Language:English
Subjects:
Administration, Intravenous
Administration, Oral
Adult
Aged
Aged, 80 and over
Ambulatory Care - methods
Ambulatory Care - psychology
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Canada
Cancer
Cancer patients
Care and treatment
Chemotherapy
Female
Fever - etiology
Fever - therapy
Financing, Personal
Hematology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasms - complications
Neoplasms - psychology
Neutropenia
Neutropenia - etiology
Neutropenia - therapy
Nursing
Nursing Research
Oncology
Original Article
Pain Measurement
Pain Medicine
Patient Preference
Quality of Life
Rehabilitation Medicine
Side effects
Strategic planning (Business)
Young Adult
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Summary:Purpose To describe anticipated health-related quality of life (HRQL) for different hypothetical strategies of febrile neutropenia (FN) management in adult cancer patients. Methods Seventy-eight adult cancer patients were enrolled. Our study considered four different hypothetical treatment strategies for FN: (1) entire inpatient management with intravenous (IV) antibiotics; (2) oral treatment at home after an initial observation in hospital with IV antibiotics; (3) entire outpatient management with IV antibiotics; and (4) entire outpatient management with oral antibiotics. Initially, patients were asked to rank the different treatment strategies for FN based on their personal preference. Subsequently, HRQL was rated using visual analog scale (VAS), time trade-off (TTO), and willingness-to-pay (WTP). Results Seventy-five percent of all respondents preferred an outpatient strategy for FN (36% oral, 21% intravenous, 18% early discharge). Further, outpatient strategies were associated with higher mean VAS scores (possible range 0–10) (oral: 6.1 (standard deviation (SD) 3.1); intravenous: 6.2 (SD 2.2); early discharge: 5.7 (SD 2.1)) as compared to inpatient care (5.3 (SD 2.9)). On the aggregate level, patients were willing to give up between 9 and 10 weeks of their life (TTO; corresponding to
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-012-1397-8