Management of WHO grade II and II meningiomas: retrospective study of surgical series of 36 cases at a single institution

Atypical and malignant meningiomas are a rare disease whose histological definition is still recent. Their management is not consensual. The aim of this study was to review the outcome, prognostic factors and the role of complementary therapies. Between 1999 and 2007, 36 patients with atypical or ma...

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Bibliographic Details
Published in:Neuro-chirurgie 2012-10, Vol.58 (5), p.275-281
Main Authors: Duntze, J, Metellus, P, Litre, C-F, Eap, C, Theret, E, Colin, P, Peruzzi, P, Rousseaux, P
Format: Article
Language:fre
Subjects:
Adult
Aged
Aged, 80 and over
Disease Progression
Disease-Free Survival
Female
Humans
Karnofsky Performance Status - statistics & numerical data
Male
Meningeal Neoplasms - mortality
Meningeal Neoplasms - radiotherapy
Meningeal Neoplasms - surgery
Meningioma - mortality
Meningioma - radiotherapy
Meningioma - surgery
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - radiotherapy
Neoplasm Recurrence, Local - surgery
Retrospective Studies
Survival Rate
Treatment Outcome
World Health Organization
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Summary:Atypical and malignant meningiomas are a rare disease whose histological definition is still recent. Their management is not consensual. The aim of this study was to review the outcome, prognostic factors and the role of complementary therapies. Between 1999 and 2007, 36 patients with atypical or malignant meningiomas were managed in our hospital. All surgical specimens were reviewed according to the 2007 WHO classification system. The sex ratio was 1.25 male, the median age was 59 years. The median follow-up was 55 months. Thirty meningiomas were atypical and six were malignant. Five and 10 years overall survival rate are respectively 72 and 41%, whereas 5 and 10 years progression free survival rate are 61 and 23%. We only identify female sex, age over 70 years and Karnofsky status under 70% as negative prognostic factors. Atypical and malignant meningiomas are difficult to manage and have high recurrence and poor survival rates. The prognostic of OMS II meningiomas is heterogeneous. Adjuvant radiation therapy is recommended in case of malignant menigioma or in case of atypical meningioma if incomplete surgical excision is performed.
ISSN:1773-0619
DOI:10.1016/j.neuchi.2012.01.006