Influence of low-molecular-weight heparin dosage on red blood cell transfusion, lymphocele rate and drainage duration after open radical prostatectomy

• Published in: European journal of surgical oncology 2012-11, Vol.38 (11), p.1082-1088
• Main Authors: Schmitges, J, Trinh, Q.-D, Jonas, L, Budäus, L, Larbig, R, Schlomm, T, Karakiewicz, P.I, Heinzer, H, Huland, H, Graefen, M, Steuber, T
• Format: Article
• Language: English
• Subjects: Aged; Anticoagulants - administration & dosage; Anticoagulants - adverse effects; Blood Loss, Surgical; Blood transfusion; Drainage; Enoxaparin - administration & dosage; Enoxaparin - adverse effects; Erythrocyte Transfusion; Hematology, Oncology and Palliative Medicine; Humans; Lymph Node Excision; Lymphocele - etiology; Male; Middle Aged; Pelvic lymphocele; Pelvis; Perioperative complications; Postoperative Care; Prostatectomy; Prostatic neoplasms; Prostatic Neoplasms - surgery; Surgery
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2012.08.002

Abstract Background To assess the rates of red blood cell (RBC) transfusions, pelvic lymphoceles, and prolonged drainage duration in patients after radical prostatectomy (RP) receiving perioperative bridging with low-molecular-weight heparin (LMWH). Patients and methods Between 2006 and 2009, 114 RP patients receiving bridging therapy with 60 mg ( n  = 63) or ≥80 mg ( n  = 51) Enoxaparin/d were compared to 1327 consecutive RP patients receiving 40 mg Enoxaparin/d. Logistic regression models were used to test the effect of LMWH dosage on all three outcomes. Covariables included age, body mass index (BMI), Charlson comorbidity index (CCI), prostate volume, pelvic lymph node dissection, and pathological stage. Results The RBC transfusion rates in patients treated with 40, 60 and ≥80 mg were 4.9, 9.5 and 19.6%, respectively ( p