Acute malignant intestinal obstruction accompanied by synchronous multifocal intestinal cancer in Peutz–Jeghers syndrome: report of a case

• Published in: Surgery today (Tokyo, Japan) Japan), 2012-11, Vol.42 (11), p.1125-1129
• Main Authors: Eren, Tunc, Bayraktar, Baris, Celik, Yahya, Boluk, Salih, Adali, Gupse
• Format: Article
• Language: English
• Subjects: Abdomen, Acute - diagnosis; Abdomen, Acute - etiology; Case Report; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Colonoscopy - methods; Duodenal Neoplasms - pathology; Duodenal Neoplasms - surgery; Duodenoscopy - methods; Emergency Service, Hospital; Follow-Up Studies; Humans; Intestinal Obstruction - etiology; Intestinal Obstruction - pathology; Intestinal Obstruction - surgery; Intestinal Polyposis - pathology; Intestinal Polyposis - surgery; Jejunal Neoplasms - complications; Jejunal Neoplasms - pathology; Jejunal Neoplasms - surgery; Laparotomy - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - surgery; Peutz-Jeghers Syndrome - complications; Peutz-Jeghers Syndrome - diagnosis; Peutz-Jeghers Syndrome - surgery; Positron-Emission Tomography - methods; Risk Assessment; Surgery; Surgical Oncology; Tomography, X-Ray Computed - methods; Treatment Outcome
• ISSN: 0941-1291; 1436-2813
• DOI: 10.1007/s00595-012-0165-1

Acute mechanical intestinal obstruction is one of the most common modes of presentation in patients with Peutz–Jeghers syndrome (PJS). This report presents a case of PJS with malignant acute jejunal obstruction accompanied by synchronous foci of duodenal, jejunal, and ileal cancer originated from hamartomatous polyps. The follow-up endoscopic findings of the patient also revealed severe polyposis of the entire gastrointestinal tract, including the stomach and colon, in addition to the small intestine. Very few cases of multifocal synchronous small intestinal cancer in PJS patients have been reported in the previous literature.