Wound Modulation After Filtration Surgery

Abstract Filtration surgery is the standard invasive procedure for the management of intraocular pressure in advanced glaucoma. The key to a successful outcome is to modulate the normal wound healing cascade that leads to closure of the newly created aqueous outflow pathway. Antifibrotic agents such...

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Bibliographic Details
Published in:Survey of ophthalmology 2012-11, Vol.57 (6), p.530-550
Main Authors: Seibold, Leonard K., MD, Sherwood, Mark B., MD, Kahook, Malik Y., MD
Format: Article
Language:English
Subjects:
Alkylating Agents - administration & dosage
Antimetabolites - administration & dosage
Biological and medical sciences
Filtering Surgery
filtration surgery
glaucoma
Glaucoma - surgery
Glaucoma and intraocular pressure
Humans
Immunosuppressive Agents - administration & dosage
Medical sciences
Miscellaneous
Ophthalmology
trabeculectomy
wound healing
Wound Healing - physiology
wound modulation
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Summary:Abstract Filtration surgery is the standard invasive procedure for the management of intraocular pressure in advanced glaucoma. The key to a successful outcome is to modulate the normal wound healing cascade that leads to closure of the newly created aqueous outflow pathway. Antifibrotic agents such as mitomycin C and 5-fluorouracil have been increasingly used to modulate the wound healing process and increase surgical success. Although these agents have proven efficacy, they also increase the risk of complications. Efforts have centered on the identification of novel agents and techniques that can influence wound modulation without these complications. We detail new agents and methods under investigation to control wound healing after filtration surgery.
ISSN:0039-6257
1879-3304
DOI:10.1016/j.survophthal.2012.01.008