Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose–response analysis of observational studies

Results from the recent meta-analysis suggested a favorable effect of dietary calcium and vitamin D levels on breast cancer risk. However, the relationship of dietary calcium and vitamin D levels with breast cancer risk is unclear. Thus, the dose–response relationship was assessed by restricted cubi...

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Bibliographic Details
Published in:Breast cancer research and treatment 2012-11, Vol.136 (1), p.309-312
Main Authors: Hong, Zhiqiang, Tian, Changwei, Zhang, Xingliang
Format: Article
Language:English
Subjects:
Alfacalcidol
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - diet therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Calcifediol
Calcium, Dietary - administration & dosage
Calcium, Dietary - metabolism
Cancer
Cancer research
Dose-Response Relationship, Drug
Female
Health aspects
Humans
Letter To The Editor
Medicine
Medicine & Public Health
Oncology
Oncology, Experimental
Risk Factors
Vitamin D
Vitamin D - administration & dosage
Vitamin D - blood
Vitamin D - metabolism
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Summary:Results from the recent meta-analysis suggested a favorable effect of dietary calcium and vitamin D levels on breast cancer risk. However, the relationship of dietary calcium and vitamin D levels with breast cancer risk is unclear. Thus, the dose–response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. Results suggested that women might suffer from the lowest risk of breast cancer with dietary calcium intake of about 600 mg/day, dietary vitamin D intake of about 400 IU/day, and serum vitamin D levels of about 30 ng/ml.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-012-2172-8