Immune response to tetanus booster in infants aged 15 months born prematurely with very low birth weight

Highlights ► Preterm infants had lower antibody levels before tetanus booster at 15 months. ► Breastfeeding was associated with higher tetanus antibody levels before booster dose. ► Lower antibody levels were found in infants born before 32 weeks of gestation. ► Preterm and full term infants had sim...

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Bibliographic Details
Published in:Vaccine 2012-10, Vol.30 (46), p.6521-6526
Main Authors: Perin, Maria Cristina Abrão Aued, Schlindwein, Carolina Frank, de Moraes-Pinto, Maria Isabel, Simão-Gurge, Raquel Maria, de Mello Almada Mimica, Ana Flavia, Goulart, Ana Lucia, dos Santos, Amélia Miyashiro Nunes
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Allergy and Immunology
Antibodies
Antibodies, Bacterial - blood
Birth weight
Breast feeding
Breastfeeding & lactation
CD4-Positive T-Lymphocytes - immunology
CD8-positive T-lymphocytes
CD8-Positive T-Lymphocytes - immunology
cell-mediated immunity
Cellular immunity
Children
Diphtheria
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Gestational age
Hepatitis
Humans
Humoral immunity
Immune response
Immune response (humoral)
Immunization
Immunization, Secondary
Infant
Infant, Newborn
Infant, Very Low Birth Weight
Infants
Interferon
interferon-gamma
Interferon-gamma - biosynthesis
low birth weight
Lymphocytes
Male
Premature birth
Premature infant
Prospective Studies
regression analysis
secondary immunization
t-test
Tetanus
Tetanus - immunology
Tetanus - prevention & control
Tetanus toxoid
Tetanus Toxoid - administration & dosage
Tetanus Toxoid - immunology
Vaccination
Vaccines
Whooping cough
Young Adult
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Description
Summary:Highlights ► Preterm infants had lower antibody levels before tetanus booster at 15 months. ► Breastfeeding was associated with higher tetanus antibody levels before booster dose. ► Lower antibody levels were found in infants born before 32 weeks of gestation. ► Preterm and full term infants had similar immune response after tetanus booster dose.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.08.056