Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: Further evidence for disease course-related immune alterations?

• Published in: Brain, behavior, and immunity behavior, and immunity, 2012-11, Vol.26 (8), p.1273-1279
• Main Authors: Busse, Stefan, Busse, Mandy, Schiltz, Kolja, Bielau, Hendrik, Gos, Tomasz, Brisch, Ralf, Mawrin, Christian, Schmitt, Andrea, Jordan, Wolfgang, Müller, Ulf J, Bernstein, Hans-Gert, Bogerts, Bernhard, Steiner, Johann
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Antibodies; Antigens, CD20 - metabolism; Autopsy; Blood-brain barrier; Blood-Brain Barrier - immunology; Blood-Brain Barrier - metabolism; Brain; CD20; CD20 antigen; CD3; CD3 antigen; Cell activation; Cell migration; Cerebrospinal fluid; Cytokines; Data processing; Disease Progression; Emotional behavior; Hippocampus; Hippocampus - cytology; Hippocampus - immunology; Hippocampus - metabolism; Histocompatibility antigen HLA; HLA-DR; HLA-DR Antigens - immunology; HLA-DR Antigens - metabolism; Humans; Inflammation; Lymphocytes; Lymphocytes - cytology; Lymphocytes - immunology; Lymphocytes - metabolism; Lymphocytes B; Lymphocytes T; Mental disorders; Microglia; Microglia - cytology; Microglia - immunology; Microglia - metabolism; Microglial cells; Mononuclear phagocyte system; Neuroimaging; Peripheral blood; Psychiatry; Psychosis; Schizophrenia; Schizophrenia, Paranoid - immunology
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2012.08.005

Highlight ► Increased lymphocyte densities were identified in the hippocampus of patients with residual schizophrenia in contrast to increased microglia in paranoid schizophrenia.