Role of ion channels and transporters in cell migration

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any cell in the body that is not motile at a given point in its life cycle. Important physiological processes intimately related to the ability of the respective cells to migrate include embryogenesis, immune d...

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Bibliographic Details
Published in:Physiological reviews 2012-10, Vol.92 (4), p.1865-1913
Main Authors: Schwab, Albrecht, Fabian, Anke, Hanley, Peter J, Stock, Christian
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Cell adhesion & migration
Cell Movement - physiology
Homeostasis
Ion Channels - metabolism
Ion Transport - physiology
Membrane Transport Proteins - metabolism
Metastasis
Proteins
Tissues
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Summary:Cell motility is central to tissue homeostasis in health and disease, and there is hardly any cell in the body that is not motile at a given point in its life cycle. Important physiological processes intimately related to the ability of the respective cells to migrate include embryogenesis, immune defense, angiogenesis, and wound healing. On the other side, migration is associated with life-threatening pathologies such as tumor metastases and atherosclerosis. Research from the last ≈ 15 years revealed that ion channels and transporters are indispensable components of the cellular migration apparatus. After presenting general principles by which transport proteins affect cell migration, we will discuss systematically the role of channels and transporters involved in cell migration.
ISSN:0031-9333
1522-1210
DOI:10.1152/physrev.00018.2011