Cerebral syphilitic gumma: a case report and review of the literature

A 45-year-old male presented with subacute onset of a right-sided hemiparesis, right homonymous hemianopsia, and slurred speech. The brain imaging revealed two separate intraparenchymal enhancing lesions. The cerebrospinal fluid rapid plasma reagin and venereal disease research laboratory test were...

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Bibliographic Details
Published in:Neurological sciences 2012-10, Vol.33 (5), p.1179-1181
Main Authors: Li, Jing-cheng, Mahta, Ali, Kim, Ryan Y., Saria, Marlon, Kesari, Santosh
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Case Report
Case reports
Central nervous system
Cerebrospinal fluid
Hemianopsia - etiology
Humans
Literature reviews
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroimaging
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Neurosyphilis - complications
Neurosyphilis - diagnosis
Neurosyphilis - drug therapy
Paresis
Paresis - etiology
Penicillin
Penicillin G - therapeutic use
Psychiatry
Reagin
speech
Speech Disorders - etiology
Syphilis
Treponema pallidum
Vision
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Summary:A 45-year-old male presented with subacute onset of a right-sided hemiparesis, right homonymous hemianopsia, and slurred speech. The brain imaging revealed two separate intraparenchymal enhancing lesions. The cerebrospinal fluid rapid plasma reagin and venereal disease research laboratory test were positive and consistent with syphilitic gumma, and the patient responded dramatically to penicillin G. Despite, currently low incidence of syphilis; CNS gummas should be in the differential of mass lesions as they are eminently treatable.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-011-0878-8