Chronic Autoimmune Thyroiditis in Industrial Areas in Brazil: A 15-Year Survey

Purpose To investigate whether there is an increased incidence of chronic autoimmune thyroiditis (CAT) in individuals living in the vicinity of industrial plants that manufacture petroleum byproducts in the state of São Paulo, Brazil. Methods Between 1989 and 2004, 6,306 patients of both sexes, from...

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Bibliographic Details
Published in:Journal of clinical immunology 2012-10, Vol.32 (5), p.1012-1018
Main Author: Zaccarelli-Marino, Maria Angela
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies
Autoantibodies - blood
Biomedical and Life Sciences
Biomedicine
Brazil - epidemiology
Child
Child, Preschool
Female
Hormones
Humans
Immunology
Incidence
Industry
Infectious Diseases
Internal Medicine
Iodide Peroxidase - immunology
Male
Medical Microbiology
Middle Aged
Petroleum
Serum levels
Sex
Steel
Thyroid
Thyroid Gland - diagnostic imaging
Thyroid hormones
Thyroiditis
Thyroiditis, Autoimmune - blood
Thyroiditis, Autoimmune - diagnosis
Thyroiditis, Autoimmune - epidemiology
Thyrotropin - blood
Thyroxine
Thyroxine - blood
Triiodothyronine
Triiodothyronine - blood
Ultrasonography
Young Adult
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Summary:Purpose To investigate whether there is an increased incidence of chronic autoimmune thyroiditis (CAT) in individuals living in the vicinity of industrial plants that manufacture petroleum byproducts in the state of São Paulo, Brazil. Methods Between 1989 and 2004, 6,306 patients of both sexes, from 5 to 78 years old were divided in two groups according to their home location: Group 1: 3,356 residents living near industrial plants that manufacture petroleum byproducts (Region A), and Group 2: 2,950 residents living far from Region A in an area with predominantly steel industries (Region B). For all patients, we measured the serum levels of antithyroglobulin antibody, antithyroperoxidase antibody, triiodothyronine, thyroxine, free thyroxine and thyrostimulating hormone. Sonographic scans of the thyroid gland were also conducted. Results The proportion of patients with CAT coming from Region A increased from 2.5 % (5 patients with CAT/200 total patients) in 1992 to 57.6 % (106 patients with CAT/184 total patients) in 2001. This striking increase was highly significant ( p  
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-012-9703-2