Thyroid gland involvement in advanced laryngeal cancer: Association with clinical and pathologic characteristics

Background Indications for thyroidectomy during laryngectomy are controversial. We examined whether clinicopathologic features can predict thyroid gland involvement, and the prognostic effect of thyroid gland involvement in patients undergoing total laryngectomy. Methods The study set out to review...

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Bibliographic Details
Published in:Head & neck 2012-11, Vol.34 (11), p.1586-1590
Main Authors: Hilly, Ohad, Raz, Raanan, Vaisbuch, Yona, Strenov, Yulia, Segal, Karl, Koren, Rumelia, Shvero, Jacob
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
cartilage ossification
Female
Hematologic and hematopoietic diseases
Humans
laryngeal cancer
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Laryngectomy - methods
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
lymph node metastases
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Prognosis
Survival Analysis
thyroid
Thyroid Gland - pathology
Thyroid Gland - surgery
Thyroid Neoplasms - pathology
Thyroid Neoplasms - secondary
Thyroid Neoplasms - surgery
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background Indications for thyroidectomy during laryngectomy are controversial. We examined whether clinicopathologic features can predict thyroid gland involvement, and the prognostic effect of thyroid gland involvement in patients undergoing total laryngectomy. Methods The study set out to review preoperative assessment, operation findings, pathologic findings, and follow‐up data. Results Thyroid gland involvement was found in 11 of 53 patients (21%) undergoing total laryngectomy and thyroidectomy. Preoperative work‐up failed to predict thyroid gland involvement. Thyroid gland involvement was associated with salvage procedures (p = .025), paratracheal metastases (p = .003), and poor overall survival (hazard ratio = 2.74, p = .008). Conclusions Thyroid gland involvement in patients undergoing total laryngectomy is frequent and is associated with poor prognosis. Preoperative assessment failed to predict thyroid gland involvement. We believe that thyroidectomy should be considered in cases with paratracheal lymphatic spread irrespective of tumor location within the larynx. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21972