Identifying novel biomarkers for cardiovascular disease risk prediction

The primary prevention of cardiovascular disease relies on the ability to identify at‐risk individuals long before the development of overt events. In the past decade, research into circulating, genetic and imaging biomarkers to augment traditional methods of risk prediction has only achieved modest...

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Bibliographic Details
Published in:Journal of internal medicine 2012-11, Vol.272 (5), p.430-439
Main Authors: Ge, Y., Wang, T. J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
biomarker
Biomarkers - metabolism
cardiovascular disease risk factors
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - prevention & control
Epidemiology
General aspects
Genomics
Humans
Medical sciences
Metabolomics
prevention
Prevention and actions
Primary Prevention - methods
Primary Prevention - standards
Proteomics
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
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Summary:The primary prevention of cardiovascular disease relies on the ability to identify at‐risk individuals long before the development of overt events. In the past decade, research into circulating, genetic and imaging biomarkers to augment traditional methods of risk prediction has only achieved modest success. Emerging technologies in the fields of genomics, metabolomics and proteomics are providing new platforms for biomarker discovery. Here, we review current concepts in the evaluation and discovery of cardiovascular biomarkers. Further research is needed to identify new biomarkers to successfully stratify risk of cardiovascular disease in low‐risk populations, as well as to test whether management strategies informed by biomarker testing are better than standard of care.
ISSN:0954-6820
1365-2796
DOI:10.1111/j.1365-2796.2012.02589.x