The effects of viral vaccination of dairy heifer calves on the incidence of respiratory disease, mortality, and growth

• Published in: Journal of dairy science 2012-11, Vol.95 (11), p.6731-6739
• Main Authors: Windeyer, M.C., Leslie, K.E., Godden, S.M., Hodgins, D.C., Lissemore, K.D., LeBlanc, S.J.
• Format: Article
• Language: English
• Subjects: Animal productions; Animals; Animals, Newborn - growth & development; Animals, Newborn - immunology; Animals, Newborn - virology; antibodies; average daily gain; Biological and medical sciences; blood proteins; bovine respiratory disease; Bovine Respiratory Disease Complex - epidemiology; Bovine Respiratory Disease Complex - immunology; Bovine Respiratory Disease Complex - mortality; Bovine Respiratory Disease Complex - prevention & control; Bovine respiratory syncytial virus; Bovine viral diarrhea virus; calves; Cattle; Cattle Diseases - immunology; Cattle Diseases - prevention & control; dairy calf; dairy cattle; dairy farming; Diarrhea Virus 1, Bovine Viral - immunology; Diarrhea Virus 2, Bovine Viral - immunology; disease incidence; Female; Food industries; Fundamental and applied biological sciences. Psychology; heifers; herds; Herpesviridae Infections - immunology; Herpesviridae Infections - prevention & control; Herpesvirus 1, Bovine - immunology; immune system; Incidence; maternal immunity; Milk and cheese industries. Ice creams; morbidity; mortality; Parainfluenza Virus 3, Bovine - immunology; pathogens; randomized clinical trials; Respiratory Syncytial Virus Infections - prevention & control; Respiratory Syncytial Virus, Bovine - immunology; Respirovirus Infections - prevention & control; Respirovirus Infections - veterinary; risk; risk reduction; Terrestrial animal productions; vaccination; Vertebrates; viral vaccines; Viral Vaccines - therapeutic use; viruses; weaning
• ISSN: 0022-0302; 1525-3198
• DOI: 10.3168/jds.2012-5828

Bovine respiratory disease (BRD) is one of the most common infectious causes of morbidity and mortality in young dairy cattle. The objective of this randomized clinical trial was to determine the effectiveness of 1 or 2 doses of a 5-way, modified-live viral vaccine, administered to heifer calves before weaning to aid in the prevention of BRD. The hypotheses were that vaccination would reduce the incidence of BRD and mortality, and that 2 doses would be more effective than 1. A total of 2,874 heifer calves from 19 commercial dairy farms in Minnesota and Ontario were enrolled at 1 to 7d of age and were followed until 3mo of age. Calves were randomly assigned to receive a commercial, intramuscular, modified-live vaccine against bovine viral diarrhea virus types 1 and 2, bovine respiratory syncytial virus, bovine herpesvirus type 1, and parainfluenza virus type 3 at 15 to 21d of age (2wk only), 35 to 42d (5wk only), both 2 and 5wk, or sterile saline at both times (unvaccinated controls). The incidence of failure of passive transfer was 11 or 32%, using cut-points of serum total protein of 5.2 and 5.7g/dL, respectively. Overall, 22% of calves were treated at least once for BRD. The incidence risk of naturally occurring BRD was 7.7% before 2wk of age, 8.0% between 2 and 5wk, and 9.5% between 5wk and 3mo of age, and was not different between vaccination groups. Overall mortality throughout the 3-mo study period was 3.5%. Mortality was 1.6% before 2wk of age, 0.5% between 2 and 5wk, and 1.2% between 5wk and 3mo of age. The risk of mortality was not affected by vaccination. Mean average daily gain of 1.07kg/d from 5wk to 3mo of age was not different between vaccine groups. In this population of commercial, home-raised calves, with an overall low incidence of failure of passive transfer, intramuscular vaccination with a multivalent, modified live viral vaccine at 2 or 5wk of age or both was not associated with a decreased risk of BRD or mortality, or with growth until 3mo of age. Reasons for these findings may include interference by maternal antibodies, unresponsiveness of the neonatal immune system, timing of immunity relative to pathogen exposure, disease caused by pathogens other than the viruses in the vaccine, or herd immunity. However, in populations with higher incidence of failure of passive transfer or risk of BRD, calves with low levels of specific antibodies may respond differently to vaccination.