A case of paravertebral mediastinal chordoma without bone destruction

We report a unique case of mediastinal paravertebral chordoma without bone destruction in a 47-year-old Japanese woman. She was admitted to hospital after a tumor was incidentally detected on a chest radiograph. The tumor was located in the paravertebral region of the mediastinum and did not show an...

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Bibliographic Details
Published in:Skeletal radiology 2012-12, Vol.41 (12), p.1641-1644
Main Authors: Matsubayashi, Jun, Sato, Eiichi, Nomura, Masaharu, Kakihana, Masatoshi, Uchida, Osamu, Saji, Hisashi, Park, Jinho, Akata, Souichi, Ikeda, Norihiko, Nagao, Toshitaka, Ishida, Tsuyoshi
Format: Article
Language:English
Subjects:
Case Report
Chordoma - complications
Chordoma - diagnosis
Chordoma - surgery
Diagnosis
Female
Humans
Imaging
Magnetic Resonance Imaging - methods
Mediastinal Neoplasms - complications
Mediastinal Neoplasms - diagnosis
Mediastinal Neoplasms - surgery
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Orthopedics
Osteolysis - diagnosis
Osteolysis - etiology
Pathology
Radiology
Spinal Neoplasms - complications
Spinal Neoplasms - diagnosis
Spinal Neoplasms - surgery
Thoracic Vertebrae - diagnostic imaging
Thoracic Vertebrae - pathology
Thoracic Vertebrae - surgery
Tomography, X-Ray Computed - methods
Treatment Outcome
Tumors, Embryonal
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Summary:We report a unique case of mediastinal paravertebral chordoma without bone destruction in a 47-year-old Japanese woman. She was admitted to hospital after a tumor was incidentally detected on a chest radiograph. The tumor was located in the paravertebral region of the mediastinum and did not show any destruction of the thoracic vertebra radiologically. The tumor was clinically diagnosed as a benign neurogenic tumor and the tumor was easily removed surgically. Microscopically, the tumor mainly consisted of tumor cells with extensively vacuolated cytoplasm, arranged in cord- and nest-like fashion against a myxoid matrix background. Immunohistochemically, the tumor cells showed diffuse positivity for pancytokeratin (AE1/AE3) and vimentin. The tumor cell nuclei were positive for brachyury, which is a key transcription factor of notochordal development. These results confirmed the tumor to be an extraosseous chordoma in the paravertebral mediastinal region, which is an extremely rare location for a chordoma.
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-012-1493-3