HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy

The occurrence of viral control after interruption of an antiretroviral treatment (ART) initiated during primary HIV-1 infection (PHI) is rare and the frequency and predictive factors of such a control are unknown. Within the French ANRS PRIMO Cohort, 164 patients interrupted ART initiated during PH...

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Bibliographic Details
Published in:Antiviral therapy 2012-01, Vol.17 (6), p.1001-1009
Main Authors: GOUJARD, Cécile, GIRAULT, Isabelle, MEYER, Laurence, SINET, Martine, ROUZIOUX, Christine, LECUROUX, Camille, DEVEAU, Christiane, CHAIX, Marie-Laure, JACOMET, Christine, TALAMALI, Amel, DELFRAISSY, Jean-François, VENET, Alain
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - administration & dosage
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active - methods
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
Drug Administration Schedule
Enzyme-Linked Immunosorbent Assay
Female
HIV Antibodies - blood
HIV Infections - drug therapy
HIV Infections - virology
HIV Seropositivity
HIV-1 - immunology
HIV-1 - pathogenicity
Human viral diseases
Humans
Immunity, Cellular
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Kaplan-Meier Estimate
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - virology
Lymphocyte Activation
Male
Medical sciences
Pharmacology. Drug treatments
RNA, Viral - blood
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load - drug effects
Viremia - drug therapy
Viremia - immunology
Virus Replication
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Summary:The occurrence of viral control after interruption of an antiretroviral treatment (ART) initiated during primary HIV-1 infection (PHI) is rare and the frequency and predictive factors of such a control are unknown. Within the French ANRS PRIMO Cohort, 164 patients interrupted ART initiated during PHI. We compared patients whose viral load (VL) remained undetectable (
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP2273