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Multiple Cutaneous Swellings Associated With Sudden Collapse

Felton and Ferguson present the case of a 77-year-old man with multiple cutaneous swellings associated with sudden collapse. He was diagnosed with blue rubber bleb nevus syndrome (BRBNS), a rare sporadic disorder of venous malformation affecting skin and viscera. In this patient, spinal MRI revealed...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2012-10, Vol.308 (16), p.1685-1686
Main Authors: Felton, Sarah J, Ferguson, Janice E
Format: Article
Language:English
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Summary:Felton and Ferguson present the case of a 77-year-old man with multiple cutaneous swellings associated with sudden collapse. He was diagnosed with blue rubber bleb nevus syndrome (BRBNS), a rare sporadic disorder of venous malformation affecting skin and viscera. In this patient, spinal MRI revealed focal intramedullary hemorrhage, from T11 to L1 with associated cord edema extending from T9 to the conus. MRI of the brain additionally highlighted multiple foci of hemorrhage, suggestive of multiple cavernomas. He received high-dose pulsed IV methylprednisolone for several days, without improvement. A representative skin lesion was excised, and histology showed the appearance of venous malformation, consistent with the diagnosis of BRBNS.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2012.13656