Long-Lived Nuclear Singlet Order in Near-Equivalent 13C Spin Pairs

Molecules that support 13C singlet states with lifetimes of over 10 min in solution have been designed and synthesized. The 13C2 spin pairs in the asymmetric alkyne derivatives are close to magnetic equivalence, so the 13C long-lived singlet states are stable in high magnetic field and do not requir...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2012-10, Vol.134 (42), p.17494-17497
Main Authors: Pileio, Giuseppe, Hill-Cousins, Joseph T, Mitchell, Sam, Kuprov, Ilya, Brown, Lynda J, Brown, Richard C. D, Levitt, Malcolm H
Format: Article
Language:English
Online Access:Get full text
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Summary:Molecules that support 13C singlet states with lifetimes of over 10 min in solution have been designed and synthesized. The 13C2 spin pairs in the asymmetric alkyne derivatives are close to magnetic equivalence, so the 13C long-lived singlet states are stable in high magnetic field and do not require maintenance by a radiofrequency spin-locking field. We suggest a model of singlet relaxation by fluctuating chemical shift anisotropy tensors combined with leakage associated with slightly broken magnetic equivalence. Theoretical estimates of singlet relaxation rates are compared with experimental values. Relaxation due to antisymmetric shielding tensor components is significant.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja3089873