Successful response to docetaxel treatment in recurrent ovarian granulosa cell tumor: a case report

Ovarian granulosa cell tumor (GCT) is primarily treated surgically. Treatment for advanced or recurrent disease includes primary or adjuvant chemotherapy. Data about the efficacy of treatment with paclitaxel are limited, without data about the role of docetaxel in treating recurrent GCT. A 68-year-o...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2012, Vol.33 (4), p.419-420
Main Authors: Shavit, T, Bruchim, I, Ben-Harim, Z, Fishman, A
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents - therapeutic use
Female
Granulosa Cell Tumor - drug therapy
Humans
Neoplasm Recurrence, Local - drug therapy
Ovarian Neoplasms - drug therapy
Taxoids - therapeutic use
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Summary:Ovarian granulosa cell tumor (GCT) is primarily treated surgically. Treatment for advanced or recurrent disease includes primary or adjuvant chemotherapy. Data about the efficacy of treatment with paclitaxel are limited, without data about the role of docetaxel in treating recurrent GCT. A 68-year-old patient with Stage IA ovarian GCT diagnosed ten years earlier, presented with a third episode of recurrent disease. Following the first event of recurrent disease, she underwent a second laparotomy followed by BEP chemotherapy. Because of new liver masses, she was treated with paclitaxel, with complete response. Following diagnosis of new liver lesions, third-line chemotherapy with docetaxel was initiated, resulting in stable disease and a PFI of 24 months. Docetaxel might be a good alternative for treating recurrent GCT.
ISSN:0392-2936