Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

It all clicks into place: A potent telomere‐targeting small molecule has been identified by using the copper‐free 1,3‐dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non‐Watson–Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-10, Vol.51 (44), p.11073-11078
Main Authors: Di Antonio, Marco, Biffi, Giulia, Mariani, Angelica, Raiber, Eun-Ang, Rodriguez, Raphaël, Balasubramanian, Shankar
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Azides - chemistry
Click Chemistry
DNA
DNA - chemistry
Fibroblasts - cytology
G-Quadruplexes
Humans
Microscopy, Fluorescence
Molecular Structure
RNA
RNA - chemistry
Telomere - chemistry
telomeres
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Summary:It all clicks into place: A potent telomere‐targeting small molecule has been identified by using the copper‐free 1,3‐dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non‐Watson–Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small‐molecule probes to selectively target a given RNA or DNA.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201206281