Tenascin-C in Cardiovascular Tissue Remodeling: From Development to Inflammation and Repair

Tenascin-C (TN-C) is a matricellular protein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues, and may regulate cell behavior and matrix organization during tissue remodeling. In the cardiovascular system, TN-C is transiently expressed at sev...

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Bibliographic Details
Published in:Circulation Journal 2012, Vol.76(11), pp.2513-2520
Main Author: Imanaka-Yoshida, Kyoko
Format: Article
Language:English
Subjects:
Animals
Biomarker
Biomarkers - metabolism
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cardiovascular System - metabolism
Cardiovascular System - pathology
Cell Adhesion
Collagenases - metabolism
Embryonic Development
Humans
Inflammation
Molecular imaging
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Myofibroblasts - metabolism
Myofibroblasts - pathology
Neovascularization, Physiologic
Remodeling
Tenascin - biosynthesis
Tenascin-C
Up-Regulation
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Summary:Tenascin-C (TN-C) is a matricellular protein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues, and may regulate cell behavior and matrix organization during tissue remodeling. In the cardiovascular system, TN-C is transiently expressed at several important steps of embryonic development, playing important roles in the differentiation of cardiomyocytes and in coronary vasculo/angiogenesis. TN-C is sparse in normal adults, but upregulated under pathological conditions such as myocarditis, myocardial infarction, cardiac fibrosis, atherosclerosis, stenotic neointimal hyperplasia, and aneurysm, and is closely associated with tissue injury and inflammation. In view of its specific expression, TN-C could be a realistic and promising biomarker and a target for molecular imaging for the diagnosis of various cardiovascular diseases. TN-C also has diverse functions, including weakening of cell adhesion, up-regulating the expression and activity of matrix metalloproteinases, modulating inflammatory responses, promoting recruitment of myofibroblasts, and enhancing fibrosis. TN-C could exert both harmful and protective effects and might be a therapeutic target as a key molecule in the control of the balance of beneficial and undesirable cellular responses during tissue remodeling.  (Circ J 2012; 76: 2513–2520)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-12-1033