Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

Phytochemicals and their synthetic derivatives are making a significant contribution in modern drug discovery programs by targeting several human diseases, including cancer. Most of these natural compounds are often multitargeted in nature, which is generally a very desirable property for cancer the...

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Published in:Biochemical pharmacology 2012-11, Vol.84 (10), p.1268-1276
Main Authors: Prasannan, Remya, Kalesh, Karunakaran A., Shanmugam, Muthu K., Nachiyappan, Alamelu, Ramachandran, Lalitha, Nguyen, An H., Kumar, Alan Prem, Lakshmanan, Manikandan, Ahn, Kwang Seok, Sethi, Gautam
Format: Article
Language:English
Subjects:
adverse effects
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
anticarcinogenic activity
Anticarcinogenic Agents - pharmacology
Anticarcinogenic Agents - therapeutic use
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Cancer
Cell Line, Tumor
chemoprevention
cost effectiveness
drugs
genes
human diseases
Humans
in vivo studies
metastasis
Neoplasm Transplantation
NF-κB
phytochemicals
Radiation-Sensitizing Agents - pharmacology
Radiation-Sensitizing Agents - therapeutic use
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Signal Transduction
therapeutics
TRAIL
Zerumbone
Zingiber zerumbet
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Summary:Phytochemicals and their synthetic derivatives are making a significant contribution in modern drug discovery programs by targeting several human diseases, including cancer. Most of these natural compounds are often multitargeted in nature, which is generally a very desirable property for cancer therapy, as carcinomas typically involve dysregulation of multiple genes and associated cell-signaling pathways at various stages of initiation, progression and metastasis. Additionally, these natural agents generally have lower side-effects, are readily available and hence are cost effective. One such natural compound is zerumbone, a cyclic eleven-membered sesquiterpene, isolated from the tropical plant Zingiber zerumbet Smith that has attracted great attention recently for its potent anticancer activities in several tumor models. This review summarizes the data based on various in vitro and in vivo studies related to the effects of zerumbone on numerous pivotal molecular targets in cancer and its reported chemopreventive/therapeutic effects in different models of cancer.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2012.07.015