Loading…
Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer
Phytochemicals and their synthetic derivatives are making a significant contribution in modern drug discovery programs by targeting several human diseases, including cancer. Most of these natural compounds are often multitargeted in nature, which is generally a very desirable property for cancer the...
Saved in:
| Published in: | Biochemical pharmacology 2012-11, Vol.84 (10), p.1268-1276 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c486t-c4512126eae214429ada2c5cd65bc0c50d29eb60ee3bd3694e01501e8ebd1b393 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c486t-c4512126eae214429ada2c5cd65bc0c50d29eb60ee3bd3694e01501e8ebd1b393 |
| container_end_page | 1276 |
| container_issue | 10 |
| container_start_page | 1268 |
| container_title | Biochemical pharmacology |
| container_volume | 84 |
| creator | Prasannan, Remya Kalesh, Karunakaran A. Shanmugam, Muthu K. Nachiyappan, Alamelu Ramachandran, Lalitha Nguyen, An H. Kumar, Alan Prem Lakshmanan, Manikandan Ahn, Kwang Seok Sethi, Gautam |
| description | Phytochemicals and their synthetic derivatives are making a significant contribution in modern drug discovery programs by targeting several human diseases, including cancer. Most of these natural compounds are often multitargeted in nature, which is generally a very desirable property for cancer therapy, as carcinomas typically involve dysregulation of multiple genes and associated cell-signaling pathways at various stages of initiation, progression and metastasis. Additionally, these natural agents generally have lower side-effects, are readily available and hence are cost effective. One such natural compound is zerumbone, a cyclic eleven-membered sesquiterpene, isolated from the tropical plant Zingiber zerumbet Smith that has attracted great attention recently for its potent anticancer activities in several tumor models. This review summarizes the data based on various in vitro and in vivo studies related to the effects of zerumbone on numerous pivotal molecular targets in cancer and its reported chemopreventive/therapeutic effects in different models of cancer. |
| doi_str_mv | 10.1016/j.bcp.2012.07.015 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1115528633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006295212004972</els_id><sourcerecordid>1115528633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c486t-c4512126eae214429ada2c5cd65bc0c50d29eb60ee3bd3694e01501e8ebd1b393</originalsourceid><addsrcrecordid>eNp9kctu1DAUQC0EotOBD2ADXrKZ4OskngRWqGoBUakS0LXlx52pR4kdbKdo-vV1NIUlG7907uuYkDfAKmAgPhwqbaaKM-AV21YM2mdkBd223vBedM_JijEmyrnlZ-Q8pcNy7QS8JGecdw1vun5F9Hc8UoPDQJPbezU4v6eTynd_1DHRMdh5UBkt1Uf6gHEedfD4kf4IA1Lnab5DOkW8R59d8FR5S3NElcfyQMOOGuUNxlfkxU4NCV8_7Wtye3X56-Lr5vrmy7eLz9cb03Qil7UFDlygQg5Nw3tlFTetsaLVhpmWWd6jFgyx1rYWfYNlYAbYobag675ek_envFMMv2dMWY4uLaMpj2FOEgDalneirgsKJ9TEkFLEnZyiG1U8SmByUSsPsqiVi1rJtrJUKjFvn9LPekT7L-KvywK8OwE7FaTaR5fk7U--NMkY59vyL2vy6URg0XDvMMpkHBZH1kU0Wdrg_tPAI3wwk08</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1115528633</pqid></control><display><type>article</type><title>Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer</title><source>ScienceDirect Journals</source><creator>Prasannan, Remya ; Kalesh, Karunakaran A. ; Shanmugam, Muthu K. ; Nachiyappan, Alamelu ; Ramachandran, Lalitha ; Nguyen, An H. ; Kumar, Alan Prem ; Lakshmanan, Manikandan ; Ahn, Kwang Seok ; Sethi, Gautam</creator><creatorcontrib>Prasannan, Remya ; Kalesh, Karunakaran A. ; Shanmugam, Muthu K. ; Nachiyappan, Alamelu ; Ramachandran, Lalitha ; Nguyen, An H. ; Kumar, Alan Prem ; Lakshmanan, Manikandan ; Ahn, Kwang Seok ; Sethi, Gautam</creatorcontrib><description>Phytochemicals and their synthetic derivatives are making a significant contribution in modern drug discovery programs by targeting several human diseases, including cancer. Most of these natural compounds are often multitargeted in nature, which is generally a very desirable property for cancer therapy, as carcinomas typically involve dysregulation of multiple genes and associated cell-signaling pathways at various stages of initiation, progression and metastasis. Additionally, these natural agents generally have lower side-effects, are readily available and hence are cost effective. One such natural compound is zerumbone, a cyclic eleven-membered sesquiterpene, isolated from the tropical plant Zingiber zerumbet Smith that has attracted great attention recently for its potent anticancer activities in several tumor models. This review summarizes the data based on various in vitro and in vivo studies related to the effects of zerumbone on numerous pivotal molecular targets in cancer and its reported chemopreventive/therapeutic effects in different models of cancer.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/j.bcp.2012.07.015</identifier><identifier>PMID: 22842489</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>adverse effects ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; anticarcinogenic activity ; Anticarcinogenic Agents - pharmacology ; Anticarcinogenic Agents - therapeutic use ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Apoptosis ; Cancer ; Cell Line, Tumor ; chemoprevention ; cost effectiveness ; drugs ; genes ; human diseases ; Humans ; in vivo studies ; metastasis ; Neoplasm Transplantation ; NF-κB ; phytochemicals ; Radiation-Sensitizing Agents - pharmacology ; Radiation-Sensitizing Agents - therapeutic use ; Sesquiterpenes - pharmacology ; Sesquiterpenes - therapeutic use ; Signal Transduction ; therapeutics ; TRAIL ; Zerumbone ; Zingiber zerumbet</subject><ispartof>Biochemical pharmacology, 2012-11, Vol.84 (10), p.1268-1276</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-c4512126eae214429ada2c5cd65bc0c50d29eb60ee3bd3694e01501e8ebd1b393</citedby><cites>FETCH-LOGICAL-c486t-c4512126eae214429ada2c5cd65bc0c50d29eb60ee3bd3694e01501e8ebd1b393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22842489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prasannan, Remya</creatorcontrib><creatorcontrib>Kalesh, Karunakaran A.</creatorcontrib><creatorcontrib>Shanmugam, Muthu K.</creatorcontrib><creatorcontrib>Nachiyappan, Alamelu</creatorcontrib><creatorcontrib>Ramachandran, Lalitha</creatorcontrib><creatorcontrib>Nguyen, An H.</creatorcontrib><creatorcontrib>Kumar, Alan Prem</creatorcontrib><creatorcontrib>Lakshmanan, Manikandan</creatorcontrib><creatorcontrib>Ahn, Kwang Seok</creatorcontrib><creatorcontrib>Sethi, Gautam</creatorcontrib><title>Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>Phytochemicals and their synthetic derivatives are making a significant contribution in modern drug discovery programs by targeting several human diseases, including cancer. Most of these natural compounds are often multitargeted in nature, which is generally a very desirable property for cancer therapy, as carcinomas typically involve dysregulation of multiple genes and associated cell-signaling pathways at various stages of initiation, progression and metastasis. Additionally, these natural agents generally have lower side-effects, are readily available and hence are cost effective. One such natural compound is zerumbone, a cyclic eleven-membered sesquiterpene, isolated from the tropical plant Zingiber zerumbet Smith that has attracted great attention recently for its potent anticancer activities in several tumor models. This review summarizes the data based on various in vitro and in vivo studies related to the effects of zerumbone on numerous pivotal molecular targets in cancer and its reported chemopreventive/therapeutic effects in different models of cancer.</description><subject>adverse effects</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>anticarcinogenic activity</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Anticarcinogenic Agents - therapeutic use</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>chemoprevention</subject><subject>cost effectiveness</subject><subject>drugs</subject><subject>genes</subject><subject>human diseases</subject><subject>Humans</subject><subject>in vivo studies</subject><subject>metastasis</subject><subject>Neoplasm Transplantation</subject><subject>NF-κB</subject><subject>phytochemicals</subject><subject>Radiation-Sensitizing Agents - pharmacology</subject><subject>Radiation-Sensitizing Agents - therapeutic use</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Sesquiterpenes - therapeutic use</subject><subject>Signal Transduction</subject><subject>therapeutics</subject><subject>TRAIL</subject><subject>Zerumbone</subject><subject>Zingiber zerumbet</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1DAUQC0EotOBD2ADXrKZ4OskngRWqGoBUakS0LXlx52pR4kdbKdo-vV1NIUlG7907uuYkDfAKmAgPhwqbaaKM-AV21YM2mdkBd223vBedM_JijEmyrnlZ-Q8pcNy7QS8JGecdw1vun5F9Hc8UoPDQJPbezU4v6eTynd_1DHRMdh5UBkt1Uf6gHEedfD4kf4IA1Lnab5DOkW8R59d8FR5S3NElcfyQMOOGuUNxlfkxU4NCV8_7Wtye3X56-Lr5vrmy7eLz9cb03Qil7UFDlygQg5Nw3tlFTetsaLVhpmWWd6jFgyx1rYWfYNlYAbYobag675ek_envFMMv2dMWY4uLaMpj2FOEgDalneirgsKJ9TEkFLEnZyiG1U8SmByUSsPsqiVi1rJtrJUKjFvn9LPekT7L-KvywK8OwE7FaTaR5fk7U--NMkY59vyL2vy6URg0XDvMMpkHBZH1kU0Wdrg_tPAI3wwk08</recordid><startdate>20121115</startdate><enddate>20121115</enddate><creator>Prasannan, Remya</creator><creator>Kalesh, Karunakaran A.</creator><creator>Shanmugam, Muthu K.</creator><creator>Nachiyappan, Alamelu</creator><creator>Ramachandran, Lalitha</creator><creator>Nguyen, An H.</creator><creator>Kumar, Alan Prem</creator><creator>Lakshmanan, Manikandan</creator><creator>Ahn, Kwang Seok</creator><creator>Sethi, Gautam</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121115</creationdate><title>Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer</title><author>Prasannan, Remya ; Kalesh, Karunakaran A. ; Shanmugam, Muthu K. ; Nachiyappan, Alamelu ; Ramachandran, Lalitha ; Nguyen, An H. ; Kumar, Alan Prem ; Lakshmanan, Manikandan ; Ahn, Kwang Seok ; Sethi, Gautam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-c4512126eae214429ada2c5cd65bc0c50d29eb60ee3bd3694e01501e8ebd1b393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>adverse effects</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>anticarcinogenic activity</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Anticarcinogenic Agents - therapeutic use</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>chemoprevention</topic><topic>cost effectiveness</topic><topic>drugs</topic><topic>genes</topic><topic>human diseases</topic><topic>Humans</topic><topic>in vivo studies</topic><topic>metastasis</topic><topic>Neoplasm Transplantation</topic><topic>NF-κB</topic><topic>phytochemicals</topic><topic>Radiation-Sensitizing Agents - pharmacology</topic><topic>Radiation-Sensitizing Agents - therapeutic use</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Sesquiterpenes - therapeutic use</topic><topic>Signal Transduction</topic><topic>therapeutics</topic><topic>TRAIL</topic><topic>Zerumbone</topic><topic>Zingiber zerumbet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prasannan, Remya</creatorcontrib><creatorcontrib>Kalesh, Karunakaran A.</creatorcontrib><creatorcontrib>Shanmugam, Muthu K.</creatorcontrib><creatorcontrib>Nachiyappan, Alamelu</creatorcontrib><creatorcontrib>Ramachandran, Lalitha</creatorcontrib><creatorcontrib>Nguyen, An H.</creatorcontrib><creatorcontrib>Kumar, Alan Prem</creatorcontrib><creatorcontrib>Lakshmanan, Manikandan</creatorcontrib><creatorcontrib>Ahn, Kwang Seok</creatorcontrib><creatorcontrib>Sethi, Gautam</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prasannan, Remya</au><au>Kalesh, Karunakaran A.</au><au>Shanmugam, Muthu K.</au><au>Nachiyappan, Alamelu</au><au>Ramachandran, Lalitha</au><au>Nguyen, An H.</au><au>Kumar, Alan Prem</au><au>Lakshmanan, Manikandan</au><au>Ahn, Kwang Seok</au><au>Sethi, Gautam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>2012-11-15</date><risdate>2012</risdate><volume>84</volume><issue>10</issue><spage>1268</spage><epage>1276</epage><pages>1268-1276</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>Phytochemicals and their synthetic derivatives are making a significant contribution in modern drug discovery programs by targeting several human diseases, including cancer. Most of these natural compounds are often multitargeted in nature, which is generally a very desirable property for cancer therapy, as carcinomas typically involve dysregulation of multiple genes and associated cell-signaling pathways at various stages of initiation, progression and metastasis. Additionally, these natural agents generally have lower side-effects, are readily available and hence are cost effective. One such natural compound is zerumbone, a cyclic eleven-membered sesquiterpene, isolated from the tropical plant Zingiber zerumbet Smith that has attracted great attention recently for its potent anticancer activities in several tumor models. This review summarizes the data based on various in vitro and in vivo studies related to the effects of zerumbone on numerous pivotal molecular targets in cancer and its reported chemopreventive/therapeutic effects in different models of cancer.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>22842489</pmid><doi>10.1016/j.bcp.2012.07.015</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 2012-11, Vol.84 (10), p.1268-1276 |
| issn | 0006-2952 1873-2968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1115528633 |
| source | ScienceDirect Journals |
| subjects | adverse effects Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use anticarcinogenic activity Anticarcinogenic Agents - pharmacology Anticarcinogenic Agents - therapeutic use Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Cancer Cell Line, Tumor chemoprevention cost effectiveness drugs genes human diseases Humans in vivo studies metastasis Neoplasm Transplantation NF-κB phytochemicals Radiation-Sensitizing Agents - pharmacology Radiation-Sensitizing Agents - therapeutic use Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Signal Transduction therapeutics TRAIL Zerumbone Zingiber zerumbet |
| title | Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T07%3A59%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Key%20cell%20signaling%20pathways%20modulated%20by%20zerumbone:%20Role%20in%20the%20prevention%20and%20treatment%20of%20cancer&rft.jtitle=Biochemical%20pharmacology&rft.au=Prasannan,%20Remya&rft.date=2012-11-15&rft.volume=84&rft.issue=10&rft.spage=1268&rft.epage=1276&rft.pages=1268-1276&rft.issn=0006-2952&rft.eissn=1873-2968&rft_id=info:doi/10.1016/j.bcp.2012.07.015&rft_dat=%3Cproquest_cross%3E1115528633%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c486t-c4512126eae214429ada2c5cd65bc0c50d29eb60ee3bd3694e01501e8ebd1b393%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1115528633&rft_id=info:pmid/22842489&rfr_iscdi=true |