Unchanged prevalence of Down syndrome in the Netherlands: results from an 11-year nationwide birth cohort

ABSTRACT Objective This study aims to evaluate trends in prevalence of Down syndrome (DS) births in the Netherlands over an 11‐year period and how they have been affected by maternal age and introduction of prenatal screening. Method Nationwide data of an 11‐year birth cohort (1997–2007) from the Ne...

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Bibliographic Details
Published in:Prenatal diagnosis 2012-11, Vol.32 (11), p.1035-1040
Main Authors: van Gameren-Oosterom, Helma B. M., Buitendijk, S. E., Bilardo, C. M., van der Pal-de Bruin, Karin M., Van Wouwe, J. P., Mohangoo, A. D.
Format: Article
Language:English
Subjects:
Abortion, Eugenic - statistics & numerical data
Abortion, Eugenic - trends
Adult
Cohort Studies
Down Syndrome - diagnostic imaging
Down Syndrome - epidemiology
Female
Humans
Male
Maternal Age
Netherlands - epidemiology
Pregnancy
Prenatal Diagnosis - statistics & numerical data
Prenatal Diagnosis - trends
Prevalence
Registries - statistics & numerical data
Ultrasonography
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Summary:ABSTRACT Objective This study aims to evaluate trends in prevalence of Down syndrome (DS) births in the Netherlands over an 11‐year period and how they have been affected by maternal age and introduction of prenatal screening. Method Nationwide data of an 11‐year birth cohort (1997–2007) from the Netherlands Perinatal Registry were analyzed. First‐trimester combined screening was introduced in 2002, free of charge only for women 36 years of age or older and only on patients' request. Changes in maternal age, prevalence of DS births, and rates of births at
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.3951