Loading…
Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer
Purpose The aim of this study was to investigate whether IL-12A, IL-12B, IL-12Rβ1, and IL-27 gene polymorphisms and serum levels of IL-12, IL-27 are associated with esophageal cancer. Methods We genotyped IL-12A gene rs568408, IL-12B gene rs3212227, IL-12Rβ1 gene 378 C/G, IL-27 gene rs153109, rs1785...
Saved in:
| Published in: | Journal of cancer research and clinical oncology 2012-11, Vol.138 (11), p.1891-1900 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c2890-ea562e054fa7cac6f3edee34b14746ea2eb1f55c1778255cb1e2fe6ce055a563 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c2890-ea562e054fa7cac6f3edee34b14746ea2eb1f55c1778255cb1e2fe6ce055a563 |
| container_end_page | 1900 |
| container_issue | 11 |
| container_start_page | 1891 |
| container_title | Journal of cancer research and clinical oncology |
| container_volume | 138 |
| creator | Tao, Yi-Peng Wang, Wan-Ling Li, Song-Yue Zhang, Jian Shi, Qi-Zhong Zhao, Fen Zhao, Bao-Sheng |
| description | Purpose
The aim of this study was to investigate whether IL-12A, IL-12B, IL-12Rβ1, and IL-27 gene polymorphisms and serum levels of IL-12, IL-27 are associated with esophageal cancer.
Methods
We genotyped IL-12A gene rs568408, IL-12B gene rs3212227, IL-12Rβ1 gene 378 C/G, IL-27 gene rs153109, rs17855750, and rs181206 polymorphisms in a case–control study of 426 esophageal cancer patients and 432 health controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and serum IL-12p40 and IL-27p28 levels were measured by enzyme-linked immunosorbent assay.
Results
Both serum IL-12p40 and IL-27p28 levels were significantly higher in controls than those in patients (
P
|
| doi_str_mv | 10.1007/s00432-012-1269-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1115530703</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1115530703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2890-ea562e054fa7cac6f3edee34b14746ea2eb1f55c1778255cb1e2fe6ce055a563</originalsourceid><addsrcrecordid>eNp9kU2O1DAQhS0EYpqBA7BB3iCxIODyT9y9bEb8jNQSEpq95bgr3RkldnB1GM0RuA4H4Uy4SYAdq2eXv1cl12PsOYg3IIR9S0JoJSsBsgJZbyrxgK3gXAGlzEO2EmChMhLqC_aE6FaUu7HyMbuQ0mohtVix71uiFDp_6lIk3uDpDjHyMfX3Q8rjsaOBeBf59a5M2L6e9d2iX37-gN9HafkBI3If95wwTwPv8Rv2xFM7k6MWCzjKNb_rTkeOlMajP6DvefAxYH7KHrW-J3y26CW7-fD-5upTtfv88fpqu6uCXG9Ehd7UEoXRrbfBh7pVuEdUugFtdY1eYgOtMQGsXcuiDaBssQ7FYopVXbJXc9sxp68T0skNHQXsex8xTeQAwBglrFAFhRkNORFlbN2Yu8HnewfCnQNwcwCuBODOAThRPC-W9lMz4P6v48_GC_ByATwF37e5fL6jf1ytN0obKJycOSpP8YDZ3aYpx7KZ_0z_BTCumaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1115530703</pqid></control><display><type>article</type><title>Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer</title><source>Springer Link</source><creator>Tao, Yi-Peng ; Wang, Wan-Ling ; Li, Song-Yue ; Zhang, Jian ; Shi, Qi-Zhong ; Zhao, Fen ; Zhao, Bao-Sheng</creator><creatorcontrib>Tao, Yi-Peng ; Wang, Wan-Ling ; Li, Song-Yue ; Zhang, Jian ; Shi, Qi-Zhong ; Zhao, Fen ; Zhao, Bao-Sheng</creatorcontrib><description>Purpose
The aim of this study was to investigate whether IL-12A, IL-12B, IL-12Rβ1, and IL-27 gene polymorphisms and serum levels of IL-12, IL-27 are associated with esophageal cancer.
Methods
We genotyped IL-12A gene rs568408, IL-12B gene rs3212227, IL-12Rβ1 gene 378 C/G, IL-27 gene rs153109, rs17855750, and rs181206 polymorphisms in a case–control study of 426 esophageal cancer patients and 432 health controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and serum IL-12p40 and IL-27p28 levels were measured by enzyme-linked immunosorbent assay.
Results
Both serum IL-12p40 and IL-27p28 levels were significantly higher in controls than those in patients (
P
< 0.01). Rs568408 AG/AA, rs3212227 CC/AC, and IL-12Rβ1 378 GG/GC genotypes were associated with significantly increased risk of esophageal cancer (rs568408: χ
2
= 5.704,
P
= 0.017; rs3212227: χ
2
= 7.689,
P
= 0.006; IL-12Rβ1 378C/G: χ
2
= 5.206,
P
= 0.023). Moreover, rs3212227 CC/AC and 378 GG/GC genotypes were observed significantly associated with decreased serum IL-12p40 level in patients compare to other genotypes (rs3212227:
t
= 2.129,
P
= 0.034; IL-12Rβ1 378 C/G:
t
= 2.178,
P
= 0.030). Furthermore, frequency of rs3212227 CC/AC genotypes was significantly higher in patients with poor differentiation than those with AA genotype (χ
2
= 4.314,
P
= 0.035).
Conclusion
Our data suggest that the impaired production of IL-12p40 and IL-27p28 behaves as risk factors for esophageal cancer occurrence. IL-12B gene rs3212227 CC/AC and IL-12Rβ1 gene 378 GG/GC genotypes, which associated with decreased IL-12p40 level, may contribute to esophageal cancer susceptibility.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-012-1269-0</identifier><identifier>PMID: 22740240</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Alleles ; Antineoplastic agents ; Biological and medical sciences ; Cancer Research ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Esophageal Neoplasms - blood ; Esophageal Neoplasms - genetics ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Hematology ; Humans ; Interleukin-12 - genetics ; Interleukin-12 Subunit p40 - blood ; Interleukin-12 Subunit p40 - genetics ; Interleukins - genetics ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Paper ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Protein Subunits - blood ; Receptors, Interleukin-12 - genetics ; Tumors</subject><ispartof>Journal of cancer research and clinical oncology, 2012-11, Vol.138 (11), p.1891-1900</ispartof><rights>Springer-Verlag 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2890-ea562e054fa7cac6f3edee34b14746ea2eb1f55c1778255cb1e2fe6ce055a563</citedby><cites>FETCH-LOGICAL-c2890-ea562e054fa7cac6f3edee34b14746ea2eb1f55c1778255cb1e2fe6ce055a563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26493451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22740240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tao, Yi-Peng</creatorcontrib><creatorcontrib>Wang, Wan-Ling</creatorcontrib><creatorcontrib>Li, Song-Yue</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Shi, Qi-Zhong</creatorcontrib><creatorcontrib>Zhao, Fen</creatorcontrib><creatorcontrib>Zhao, Bao-Sheng</creatorcontrib><title>Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
The aim of this study was to investigate whether IL-12A, IL-12B, IL-12Rβ1, and IL-27 gene polymorphisms and serum levels of IL-12, IL-27 are associated with esophageal cancer.
Methods
We genotyped IL-12A gene rs568408, IL-12B gene rs3212227, IL-12Rβ1 gene 378 C/G, IL-27 gene rs153109, rs17855750, and rs181206 polymorphisms in a case–control study of 426 esophageal cancer patients and 432 health controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and serum IL-12p40 and IL-27p28 levels were measured by enzyme-linked immunosorbent assay.
Results
Both serum IL-12p40 and IL-27p28 levels were significantly higher in controls than those in patients (
P
< 0.01). Rs568408 AG/AA, rs3212227 CC/AC, and IL-12Rβ1 378 GG/GC genotypes were associated with significantly increased risk of esophageal cancer (rs568408: χ
2
= 5.704,
P
= 0.017; rs3212227: χ
2
= 7.689,
P
= 0.006; IL-12Rβ1 378C/G: χ
2
= 5.206,
P
= 0.023). Moreover, rs3212227 CC/AC and 378 GG/GC genotypes were observed significantly associated with decreased serum IL-12p40 level in patients compare to other genotypes (rs3212227:
t
= 2.129,
P
= 0.034; IL-12Rβ1 378 C/G:
t
= 2.178,
P
= 0.030). Furthermore, frequency of rs3212227 CC/AC genotypes was significantly higher in patients with poor differentiation than those with AA genotype (χ
2
= 4.314,
P
= 0.035).
Conclusion
Our data suggest that the impaired production of IL-12p40 and IL-27p28 behaves as risk factors for esophageal cancer occurrence. IL-12B gene rs3212227 CC/AC and IL-12Rβ1 gene 378 GG/GC genotypes, which associated with decreased IL-12p40 level, may contribute to esophageal cancer susceptibility.</description><subject>Aged</subject><subject>Alleles</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Esophageal Neoplasms - blood</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hematology</subject><subject>Humans</subject><subject>Interleukin-12 - genetics</subject><subject>Interleukin-12 Subunit p40 - blood</subject><subject>Interleukin-12 Subunit p40 - genetics</subject><subject>Interleukins - genetics</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Protein Subunits - blood</subject><subject>Receptors, Interleukin-12 - genetics</subject><subject>Tumors</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kU2O1DAQhS0EYpqBA7BB3iCxIODyT9y9bEb8jNQSEpq95bgr3RkldnB1GM0RuA4H4Uy4SYAdq2eXv1cl12PsOYg3IIR9S0JoJSsBsgJZbyrxgK3gXAGlzEO2EmChMhLqC_aE6FaUu7HyMbuQ0mohtVix71uiFDp_6lIk3uDpDjHyMfX3Q8rjsaOBeBf59a5M2L6e9d2iX37-gN9HafkBI3If95wwTwPv8Rv2xFM7k6MWCzjKNb_rTkeOlMajP6DvefAxYH7KHrW-J3y26CW7-fD-5upTtfv88fpqu6uCXG9Ehd7UEoXRrbfBh7pVuEdUugFtdY1eYgOtMQGsXcuiDaBssQ7FYopVXbJXc9sxp68T0skNHQXsex8xTeQAwBglrFAFhRkNORFlbN2Yu8HnewfCnQNwcwCuBODOAThRPC-W9lMz4P6v48_GC_ByATwF37e5fL6jf1ytN0obKJycOSpP8YDZ3aYpx7KZ_0z_BTCumaA</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Tao, Yi-Peng</creator><creator>Wang, Wan-Ling</creator><creator>Li, Song-Yue</creator><creator>Zhang, Jian</creator><creator>Shi, Qi-Zhong</creator><creator>Zhao, Fen</creator><creator>Zhao, Bao-Sheng</creator><general>Springer-Verlag</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer</title><author>Tao, Yi-Peng ; Wang, Wan-Ling ; Li, Song-Yue ; Zhang, Jian ; Shi, Qi-Zhong ; Zhao, Fen ; Zhao, Bao-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2890-ea562e054fa7cac6f3edee34b14746ea2eb1f55c1778255cb1e2fe6ce055a563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Esophageal Neoplasms - blood</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hematology</topic><topic>Humans</topic><topic>Interleukin-12 - genetics</topic><topic>Interleukin-12 Subunit p40 - blood</topic><topic>Interleukin-12 Subunit p40 - genetics</topic><topic>Interleukins - genetics</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Protein Subunits - blood</topic><topic>Receptors, Interleukin-12 - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tao, Yi-Peng</creatorcontrib><creatorcontrib>Wang, Wan-Ling</creatorcontrib><creatorcontrib>Li, Song-Yue</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Shi, Qi-Zhong</creatorcontrib><creatorcontrib>Zhao, Fen</creatorcontrib><creatorcontrib>Zhao, Bao-Sheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tao, Yi-Peng</au><au>Wang, Wan-Ling</au><au>Li, Song-Yue</au><au>Zhang, Jian</au><au>Shi, Qi-Zhong</au><au>Zhao, Fen</au><au>Zhao, Bao-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2012-11</date><risdate>2012</risdate><volume>138</volume><issue>11</issue><spage>1891</spage><epage>1900</epage><pages>1891-1900</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>Purpose
The aim of this study was to investigate whether IL-12A, IL-12B, IL-12Rβ1, and IL-27 gene polymorphisms and serum levels of IL-12, IL-27 are associated with esophageal cancer.
Methods
We genotyped IL-12A gene rs568408, IL-12B gene rs3212227, IL-12Rβ1 gene 378 C/G, IL-27 gene rs153109, rs17855750, and rs181206 polymorphisms in a case–control study of 426 esophageal cancer patients and 432 health controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and serum IL-12p40 and IL-27p28 levels were measured by enzyme-linked immunosorbent assay.
Results
Both serum IL-12p40 and IL-27p28 levels were significantly higher in controls than those in patients (
P
< 0.01). Rs568408 AG/AA, rs3212227 CC/AC, and IL-12Rβ1 378 GG/GC genotypes were associated with significantly increased risk of esophageal cancer (rs568408: χ
2
= 5.704,
P
= 0.017; rs3212227: χ
2
= 7.689,
P
= 0.006; IL-12Rβ1 378C/G: χ
2
= 5.206,
P
= 0.023). Moreover, rs3212227 CC/AC and 378 GG/GC genotypes were observed significantly associated with decreased serum IL-12p40 level in patients compare to other genotypes (rs3212227:
t
= 2.129,
P
= 0.034; IL-12Rβ1 378 C/G:
t
= 2.178,
P
= 0.030). Furthermore, frequency of rs3212227 CC/AC genotypes was significantly higher in patients with poor differentiation than those with AA genotype (χ
2
= 4.314,
P
= 0.035).
Conclusion
Our data suggest that the impaired production of IL-12p40 and IL-27p28 behaves as risk factors for esophageal cancer occurrence. IL-12B gene rs3212227 CC/AC and IL-12Rβ1 gene 378 GG/GC genotypes, which associated with decreased IL-12p40 level, may contribute to esophageal cancer susceptibility.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22740240</pmid><doi>10.1007/s00432-012-1269-0</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2012-11, Vol.138 (11), p.1891-1900 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1115530703 |
| source | Springer Link |
| subjects | Aged Alleles Antineoplastic agents Biological and medical sciences Cancer Research Case-Control Studies Enzyme-Linked Immunosorbent Assay Esophageal Neoplasms - blood Esophageal Neoplasms - genetics Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genetic Predisposition to Disease Genotype Hematology Humans Interleukin-12 - genetics Interleukin-12 Subunit p40 - blood Interleukin-12 Subunit p40 - genetics Interleukins - genetics Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Oncology Original Paper Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Protein Subunits - blood Receptors, Interleukin-12 - genetics Tumors |
| title | Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T09%3A28%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Associations%20between%20polymorphisms%20in%20IL-12A,%20IL-12B,%20IL-12R%CE%B21,%20IL-27%20gene%20and%20serum%20levels%20of%20IL-12p40,%20IL-27p28%20with%20esophageal%20cancer&rft.jtitle=Journal%20of%20cancer%20research%20and%20clinical%20oncology&rft.au=Tao,%20Yi-Peng&rft.date=2012-11&rft.volume=138&rft.issue=11&rft.spage=1891&rft.epage=1900&rft.pages=1891-1900&rft.issn=0171-5216&rft.eissn=1432-1335&rft.coden=JCROD7&rft_id=info:doi/10.1007/s00432-012-1269-0&rft_dat=%3Cproquest_cross%3E1115530703%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2890-ea562e054fa7cac6f3edee34b14746ea2eb1f55c1778255cb1e2fe6ce055a563%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1115530703&rft_id=info:pmid/22740240&rfr_iscdi=true |