No association between catechol- O -methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students

Abstract This study investigates the genetic association between catechol- O -methyltransferase (COMT) gene polymorphisms and neurotic disorders. Data were derived from a case–control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate control...

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Bibliographic Details
Published in:Psychiatry research 2012-07, Vol.198 (2), p.313-315
Main Authors: Kou, Changgui, Meng, Xiangfei, Xie, Bing, Shi, Jieping, Yu, Qiong, Yu, Yaqin, D'Arcy, Carl
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Asian Continental Ancestry Group - genetics
Asian Continental Ancestry Group - psychology
Biological and medical sciences
Case-Control Studies
Catechol O-Methyltransferase - genetics
Catechol-O-methyltransferase
Female
Genetic Association Studies - methods
Genetic Association Studies - statistics & numerical data
Genetic Predisposition to Disease - genetics
Humans
Male
Medical sciences
Miscellaneous
Neurotic disorders
Neurotic Disorders - genetics
Polymorphism, Single Nucleotide
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Students - psychology
Tag SNP
Universities
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Summary:Abstract This study investigates the genetic association between catechol- O -methyltransferase (COMT) gene polymorphisms and neurotic disorders. Data were derived from a case–control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate controls. The polymorphisms of eight tag single nucleotide polymorphisms (SNPs) on the COMT gene were tested using polymerase chain reaction (PCR)-based Ligase Detection Reaction (PCR-LDR). The eight tag SNPs on the COMT gene assessed were not associated with neurotic disorders. Our finding suggests that the COMT gene may not be a susceptibility gene for neurotic disorders.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2011.10.020