Effect of atorvastatin on dynamic parameters of myocardial repolarization in healthy subjects

• Published in: Journal of electrocardiology 2012-11, Vol.45 (6), p.752-757
• Main Authors: Toman, Ondrej, MD, PhD, Novotny, Tomas, MD, PhD, Sisakova, Martina, MD, PhD, Hnatkova, Katerina, PhD, Andrsova, Irena, MD, Parenica, Jiri, MD, PhD, Poloczek, Martin, MD, Jenysova, Radmila, Manouskova, Lenka, Spinar, Jindrich, MD, PhD, Malik, Marek, MD, PhD
• Format: Article
• Language: English
• Subjects: Adult; Atorvastatin; Atorvastatin Calcium; Cardiovascular; Dose-Response Relationship, Drug; Double-Blind Method; ECG; Electrocardiography - drug effects; Female; Heart Rate - drug effects; Heptanoic Acids - administration & dosage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Male; Myocardial repolarization; Pyrroles - administration & dosage; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method
• ISSN: 0022-0736; 1532-8430
• DOI: 10.1016/j.jelectrocard.2012.06.020

Abstract Background Antiarrhythmic properties of statins were suggested as a part of their pleiotropic effects. The aim of the present study was to evaluate the effects of atorvastatin on myocardial repolarization as manifested on surface electrocardiograms (ECGs) in healthy subjects. Methods and Results Forty young healthy volunteers (20 men, 20 women) underwent a single-dose double-blind 3-way crossover study of 20 and 80 mg of atorvastatin and placebo. Long-term 13-hour 12-lead ECGs were obtained in each subject and each study period starting 15 minutes before drug administration. Each study period contained 18 time-points of 5-minute durations when the subjects were in resting supine positions. Digital ECG recordings were analyzed automatically, and the results were completed blindly before statistical analyses. Dynamic parameters of myocardial repolarization and T-wave morphology descriptors were evaluated. Although some trends were observed, no significant drug-related changes in any of investigated ECG repolarization descriptors were found. Conclusion In comparison with placebo, single doses of atorvastatin had no effect on repolarization heterogeneity in healthy subjects. The observation confirms safe profile of the drug with limited proarrhythmic potential.