The role of prophylactic antimicrobials during autologous stem cell transplantation: a single-center experience

The aim of this study was to investigate the efficacy of antibiotic prophylaxis in patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma and non-Hodgkin lymphoma. Among 232 ASCT cases performed at the Asan Medical Center, 114 cases underwent treatment with ciprofloxaci...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2012-07, Vol.31 (7), p.1653-1661
Main Authors: Sohn, B. S., Yoon, D. H., Kim, S., Lee, K., Kang, E. H., Park, J. S., Lee, D. H., Kim, S. H., Huh, J., Suh, C.
Format: Article
Language:English
Subjects:
acyclovir
Acyclovir - administration & dosage
Adolescent
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Antibiotics
Antifungal Agents - administration & dosage
Antimicrobial agents
Antiviral Agents - administration & dosage
Autografts
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Chemoprevention - methods
Chemotherapy
Ciprofloxacin
Ciprofloxacin - administration & dosage
Disease prevention
Drug dosages
E coli
Escherichia coli
Escherichia coli - isolation & purification
Female
Fever
Fever of Unknown Origin - epidemiology
Fever of Unknown Origin - prevention & control
fluconazole
Fluconazole - administration & dosage
Humans
Immunocompromised Host
Incidence
Infection
Infections
Infectious diseases
Internal Medicine
Lymphoma
Male
Medical Microbiology
Medical schools
Medical sciences
Medicine
Middle Aged
Mortality
Multiple myeloma
Neutropenia
Neutrophils
Prophylaxis
Staphylococcus aureus
Staphylococcus aureus - isolation & purification
Stem cell transplantation
Stem Cell Transplantation - adverse effects
Stem cells
Treatment Outcome
Young Adult
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Summary:The aim of this study was to investigate the efficacy of antibiotic prophylaxis in patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma and non-Hodgkin lymphoma. Among 232 ASCT cases performed at the Asan Medical Center, 114 cases underwent treatment with ciprofloxacin, fluconazole, and acyclovir (between January 2001 and August 2005), while 118 cases were performed without antimicrobial prophylaxis (between February 2004 and June 2008). The two-rate χ 2 test was applied to accommodate the differences in neutropenia duration. The incidence of febrile episodes was 9.8 cases per 100 person-days in the prophylactic group, while it was 16.2 cases in the no-prophylactic group ( p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-011-1489-2