Antigenic sites of H1N1 influenza virus hemagglutinin revealed by natural isolates and inhibition assays

Highlights ► We infer 41 residues and 5 epitopes of H1N1 HA for antigenic evolution. ► Epitopes A, B and C are critical for escaping from antibody. ► Entropy and LR can reflect genetic diversity and antigenic variant. ► Our model is useful for WHO vaccine strain selections.

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Bibliographic Details
Published in:Vaccine 2012-09, Vol.30 (44), p.6327-6337
Main Authors: Huang, Jhang-Wei, Lin, Wei-Fan, Yang, Jinn-Moon
Format: Article
Language:English
Subjects:
Allergy and Immunology
Amino acids
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antigenic drift
Antigenic site
Antigenic variants
Antigenic Variation
Computer Simulation
Entropy
Epidemics
Epitopes
Epitopes - genetics
Epitopes - immunology
Evolution
Evolution & development
Evolution, Molecular
Genetic diversity
H1N1 virus
hemagglutination
Hemagglutination inhibition
Hemagglutination Inhibition Tests
Hemagglutinin
Hemagglutinin Glycoproteins, Influenza Virus - genetics
Hemagglutinin Glycoproteins, Influenza Virus - immunology
Hemagglutinins
Humans
Immune system
Influenza
Influenza A virus
Influenza A Virus, H1N1 Subtype - genetics
Influenza A Virus, H1N1 Subtype - immunology
Influenza vaccine
Influenza virus
Laboratories
Methods
Mutation
Mutation, Missense
neutralizing antibodies
prediction
Statistical analysis
Surveillance
Swine flu
Vaccines
Viruses
World Health Organization
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Description
Summary:Highlights ► We infer 41 residues and 5 epitopes of H1N1 HA for antigenic evolution. ► Epitopes A, B and C are critical for escaping from antibody. ► Entropy and LR can reflect genetic diversity and antigenic variant. ► Our model is useful for WHO vaccine strain selections.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.07.079