Tubercle bacilli rely on a type VII army for pathogenicity

Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secre...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2012-10, Vol.20 (10), p.477-484
Main Authors: Stoop, Esther J.M, Bitter, Wilbert, van der Sar, Astrid M
Format: Article
Language:English
Subjects:
Bacterial Proteins - secretion
Bacterial Secretion Systems
ESX
granuloma formation
Humans
hydrophobicity
Internal Medicine
Models, Biological
mycobacteria
Mycobacterium tuberculosis
Mycobacterium tuberculosis - pathogenicity
pathogens
protein secretion
Protein Transport
tuberculosis
type VII secretion
virulence
Virulence Factors - metabolism
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Summary:Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secretion (T7S) pathway has been identified that fulfills this function. Pathogenic mycobacteria have up to five different T7S systems, some of which play a crucial role in virulence. The interactions between secreted substrates and host molecules are only starting to become clear and will help in furthering our understanding of the persistence of these enigmatic pathogens. In this review, we discuss current knowledge on the role of T7S systems in mycobacterial virulence.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2012.07.001