New classes of antibiotics

Highlights ► We review 11 new antibiotics with novel structures in clinical trials. ► Most inhibit bacterial targets which are not inhibited by current antibiotics. ► The spectrum ranges from Gram-negative to Gram-positive to mycobacteria. ► Most of the targets have not been explored previously or w...

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Bibliographic Details
Published in:Current opinion in pharmacology 2012-10, Vol.12 (5), p.535-544
Main Authors: Moir, Donald T, Opperman, Timothy J, Butler, Michelle M, Bowlin, Terry L
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Clinical Trials as Topic
Humans
Internal Medicine
Medical Education
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Summary:Highlights ► We review 11 new antibiotics with novel structures in clinical trials. ► Most inhibit bacterial targets which are not inhibited by current antibiotics. ► The spectrum ranges from Gram-negative to Gram-positive to mycobacteria. ► Most of the targets have not been explored previously or were explored unsuccessfully in the past.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2012.07.004