Discrepancy between minimal inhibitory concentration to enrofloxacin and mutations present in the quinolone-resistance determining regions of Mycoplasma gallisepticum field strains

Molecular characterization of the quinolone-resistance determining regions (QRDRs) of DNA gyrase and topoisomerase IV in 93 Mycoplasma gallisepticum field strains isolated in different geographic regions revealed discrepancies between minimal inhibitory concentration values and presence of amino aci...

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Bibliographic Details
Published in:Veterinary microbiology 2012-11, Vol.160 (1-2), p.222-226
Main Authors: Lysnyansky, I., Gerchman, I., Levisohn, S., Mikula, I., Feberwee, A., Ferguson, N.M., Noormohammadi, A.H., Spergser, J., Windsor, H.M.
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Animals
Bacteriology
Biological and medical sciences
Birds
DNA Gyrase - genetics
DNA Topoisomerase IV - chemistry
DNA Topoisomerase IV - genetics
Enrofloxacin
Enrofloxacin susceptibility and mutations in the QRDRs in M. gallisepticum
Fluoroquinolone
Fluoroquinolones - pharmacology
Fundamental and applied biological sciences. Psychology
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Mutation
Mycoplasma gallisepticum
Mycoplasma gallisepticum - drug effects
Mycoplasma gallisepticum - genetics
Mycoplasma gallisepticum - isolation & purification
Mycoplasma Infections - microbiology
Poultry Diseases - microbiology
Quinolones - pharmacology
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Summary:Molecular characterization of the quinolone-resistance determining regions (QRDRs) of DNA gyrase and topoisomerase IV in 93 Mycoplasma gallisepticum field strains isolated in different geographic regions revealed discrepancies between minimal inhibitory concentration values and presence of amino acid substitutions within the QRDRs of GyrA and ParC in 9/93 (10%) strains. This may delimitate applicability of a gene-based assay to detect fluoroquinolone resistance in this avian pathogen.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2012.05.002